Diagnostic utility of B-type natriuretic peptide in critically ill patients with pulmonary edema: a prospective cohort study

Critical Care : the Official Journal of the Critical Care Forum
Joseph E LevittJohn P Kress

Abstract

Distinguishing pulmonary edema due to acute lung injury (ALI) or the acute respiratory distress syndrome (ARDS) from hydrostatic or cardiogenic edema is challenging in critically ill patients. B-type natriuretic peptide (BNP) can effectively identify congestive heart failure in the emergency room setting but, despite increasing use, its diagnostic utility has not been validated in the intensive care unit (ICU). We performed a prospective, blinded cohort study in the medical and surgical ICUs at the University of Chicago Hospitals. Patients were eligible if they were admitted to the ICU with respiratory distress, bilateral pulmonary edema and a central venous catheter suggesting either high-pressure (cardiogenic) or low-pressure (ALI/ARDS) pulmonary edema. BNP levels were measured within 48 hours of ICU admission and development of pulmonary edema and onward up to three consecutive days. All levels were drawn simultaneously with the measurement of right atrial or pulmonary artery wedge pressure. The etiology of pulmonary edema--cardiogenic or ALI/ARDS--was determined by three intensivists blinded to BNP levels. We enrolled a total of 54 patients (33 with ALI/ARDS and 21 with cardiogenic edema). BNP levels were lower in patients ...Continue Reading

References

Mar 31, 1989·Biochemical and Biophysical Research Communications·M KojimaH Matsuo
Mar 31, 1989·Biochemical and Biophysical Research Communications·T SudohH Matsuo
Sep 1, 1988·The American Review of Respiratory Disease·J F MurrayM R Flick
Oct 1, 1985·Critical Care Medicine·W A KnausJ E Zimmerman
Mar 1, 1994·American Journal of Respiratory and Critical Care Medicine·G R BernardR Spragg
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Jul 19, 2002·The New England Journal of Medicine·Alan S MaiselUNKNOWN Breathing Not Properly Multinational Study Investigators
Oct 11, 2002·The New England Journal of Medicine·Stavros KonstantinidesUNKNOWN Management Strategies and Prognosis of Pulmonary Embolism-3 Trial Investigators
Feb 13, 2004·The New England Journal of Medicine·Christian MuellerAndré P Perruchoud
Apr 20, 2004·Critical Care Medicine·Julien CharpentierJean-Daniel Chiche
Jun 10, 2004·Critical Care Medicine·Gordon D RubenfeldLeonard D Hudson
Jun 15, 2004·The American Journal of Cardiology·Alan H B WuFred S Apple
Aug 3, 2004·Critical Care Medicine·Roderick H TungJames L Januzzi
Mar 2, 2006·Critical Care : the Official Journal of the Critical Care Forum·James L JanuzziElizabeth Lee-Lewandrowski
May 23, 2006·The New England Journal of Medicine·UNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials NetworkAndrea L Harabin
May 23, 2006·The New England Journal of Medicine·UNKNOWN National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials NetworkAndrea L Harabin

❮ Previous
Next ❯

Citations

Feb 22, 2012·Medizinische Klinik, Intensivmedizin und Notfallmedizin·S Reith, N Marx
Apr 23, 2009·American Journal of Respiratory and Critical Care Medicine·Robert A FowlerGordon D Rubenfeld
May 19, 2009·Critical Care : the Official Journal of the Critical Care Forum·Sunghoon ParkKi-Suck Jung
Oct 30, 2009·Critical Care : the Official Journal of the Critical Care Forum·Luigi CamporotaDavid Bennett
May 19, 2010·Biomarkers in Medicine·Romain PirracchioAlexandre Mebazaa
Dec 19, 2014·Journal of Intensive Care·Seitaro Fujishima
Mar 29, 2011·Critical Care Clinics·Corey E Ventetuolo, Mitchell M Levy
May 16, 2009·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Y Ozier, P-M Mertes
Oct 4, 2008·Congestive Heart Failure·Christian MuellerGerasimos S Filippatos
Sep 18, 2012·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Munish GoyalDavid F Gaieski
Nov 3, 2010·European Journal of Heart Failure·Markus NoveanuChristian Mueller
Mar 31, 2016·Archives of Pathology & Laboratory Medicine·Yasmeen ButtTimothy Craig Allen
Mar 29, 2016·Chest·Matthew W SemlerUNKNOWN NIH NHLBI ARDS Network
Jul 17, 2009·Current Opinion in Critical Care·Markus NoveanuChristian Mueller
Mar 2, 2010·Yonsei Medical Journal·Shih-Hung TsaiShu-Meng Cheng
Dec 3, 2014·European Respiratory Review : an Official Journal of the European Respiratory Society·Maurizio ZompatoriLuca Fasano
Aug 27, 2017·Critical Care : the Official Journal of the Critical Care Forum·Kosaku KomiyaBruce K Rubin
Nov 19, 2019·The Western Journal of Emergency Medicine·Brit LongMichael Gottlieb
Dec 22, 2019·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Bram RochwergAzim S Gangji
May 23, 2020·Metabolites·Sayed M Metwaly, Brent W Winston

❮ Previous
Next ❯

Methods Mentioned

BETA
RAP
blood draw
blood draws

Software Mentioned

Analyse
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.