Diagnostic utility of epigenetics in breast cancer - A review

Cancer Treatment and Research Communications
Showkat Ahmad BhatSamia Rashid

Abstract

Epigenetic alterations are clearly involved in cancer initiation and progression as recent epigenetic studies of genomic DNA, histone modifications and micro-RNA alterations suggest that these are playing an important role in the incidence of breast cancer. Epigenetic information has recently gained the attention of researchers because epigenetic modification of the genome in breast cancer is still an evolving area for researchers. Several active compounds present in foods, poisons, drugs, and industrial chemicals may as a result of epigenetic mechanisms increase or decrease the risk of breast cancer. Epigenetic regulation is critical in normal growth and development and closely conditions the transcriptional potential of genes. Epigenetic mechanisms convey genomic adaption to an environment thereby ultimately contributing towards given phenotype. In addition to the use of epigenetic alterations as a means of screening, epigenetic alterations in a tumor or adjacent tissues or peripheral blood may also help clinicians in determining prognosis and treatment of breast cancer. As we understand specific epigenetic alterations contributing to breast tumorigenesis and prognosis, these discoveries will lead to significant advances for ...Continue Reading

Citations

Nov 7, 2019·British Journal of Pharmacology·Micah G DonovanDonato F Romagnolo
May 14, 2020·Cells·Flavia Lima Costa FaldoniSilvia Regina Rogatto
Oct 13, 2020·Biochemistry. Biokhimii︠a︡·M V NemtsovaA A Zamyatnin

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