Diagnostic utility of fluorodeoxyglucose positron emission tomography in prosthetic joint infection based on MSIS criteria

The Bone & Joint Journal
M KiranV Peter

Abstract

Prosthetic joint infection (PJI) and aseptic loosening in total hip arthroplasty (THA) can present with pain and osteolysis. The Musculoskeletal Infection Society (MSIS) has provided criteria for the diagnosis of PJI. The aim of our study was to analyze the utility of F18-fluorodeoxyglucose (FDG) positron emission tomography (PET) CT scan in the preoperative diagnosis of septic loosening in THA, based on the current MSIS definition of prosthetic joint infection. A total of 130 painful unilateral cemented THAs with a mean follow-up of 5.17 years (sd 1.12) were included in this prospective study. The mean patient age was 67.5 years (sd 4.85). Preoperative evaluation with inflammatory markers, aspiration, and an F18 FDG PET scan were performed. Diagnostic utility tests were also performed, based on the MSIS criteria for PJI and three samples positive on culture alone. The mean erythrocyte sedimentation rate, C-reactive protein, and white cell count were 47.83 mm/hr, 25.21 mg/l, and 11.05 × 109/l, respectively. The sensitivity, specificity, accuracy, negative predictive value, and false-positive rate of FDG PET compared with MSIS criteria were 94.87%, 38.46 %, 56.38%, 94.59 %, and 60.21%, respectively. The false-positive rate of FD...Continue Reading

References

Sep 25, 2002·European Journal of Nuclear Medicine and Molecular Imaging·Hongming ZhuangAbass Alavi
May 27, 2003·Nuclear Medicine Communications·T K ChackoA Alavi
Mar 30, 2005·The Journal of Bone and Joint Surgery. British Volume·P ReinartzU Buell
Apr 12, 2005·Archives of Orthopaedic and Trauma Surgery·T MummeD C Wirtz
Aug 21, 2007·Radiologic Clinics of North America·Hongming ZhuangAbass Alavi
Feb 8, 2008·The Journal of Bone and Joint Surgery. British Volume·S NagoyaT Yamashita
Apr 19, 2008·Clinical Orthopaedics and Related Research·Timothy ChryssikosAbass Alavi
Aug 16, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Thomas C KweeAbass Alavi
Sep 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Mark F SchinskyWayne G Paprosky
Nov 29, 2008·Seminars in Nuclear Medicine·Charito LoveChristopher J Palestro
Sep 23, 2011·Clinical Orthopaedics and Related Research·Javad ParviziCharalampos G Zalavras
Dec 2, 2017·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Daniel S HillJonathan Howell

❮ Previous
Next ❯

Citations

Feb 23, 2020·Annals of Nuclear Medicine·Yaming LiXiao-Feng Li
Oct 1, 2020·The Bone & Joint Journal·S-T Jerry TsangA Hamish R W Simpson
Mar 2, 2021·The Bone & Joint Journal·Daniel C PerryFares S Haddad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.