Diagnostic utility of gut α-synuclein in Parkinson's disease: A systematic review and meta-analysis

Behavioural Brain Research
Jin BuZhaohui Wang

Abstract

The accumulation of misfolded α-synuclein in the brain is associated with Parkinson's disease. However, the association between gut α-synuclein and PD and diagnostic value of α-synuclein in the gut still remain controversial. A literature search from inception to June 2018 was conducted, yielding 21 studies eligible for a systematic review and meta-analysis. We included studies that reported data on gut α-synuclein or phosphorylated α-synuclein in patients with PD and controls. The odds ratio(OR) was pooled using random-effect models, and heterogeneity was reported as I2. Studies were assessed for quality using the Newcastle-Ottawa Scale. Sensitivity and specificity analyses were performed using the summary receiver operating characteristics curve approach. The database search yielded 395 results, of which 21 studies were deemed relevant. The PD group had a pooled OR of 10.01 (95% CI: 3.15-31.82, I2 = 72%) for gut α-synuclein compared with the control group. Sensitivity and specificity for distinguishing PD from controls were 0.568 and 0.819, respectively, for the colon, and 0.579 and 0.822, respectively, for phosphorylated α-synuclein. Heterogeneity was high in most of the studies. This systematic review and meta-analysis confi...Continue Reading

Citations

Apr 8, 2020·Chemistry : a European Journal·Paula OrtegaSara de Pablo
Apr 16, 2021·Acta Biomaterialia·Adam J BindasAbigail N Koppes
May 28, 2021·NPJ Parkinson's Disease·M CamachoC H Williams-Gray
Jul 27, 2021·Frontiers in Aging Neuroscience·Upasana GangulySasanka Chakrabarti

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