Diagnostic utility of immunohistochemical panel in various thyroid pathologies.

Langenbeck's Archives of Surgery
Arturs OzolinsJanis Gardovskis

Abstract

For management of thyroid nodules, distinction between benign and malignant tumours is essential. The study was performed to evaluate the diagnostic value of molecular markers in different thyroid tumours. Immunohistochemistry for CD56, HBME-1, COX-2, Ki-67, p53 and E-cadherin (E-CAD) was performed in 113 benign and 35 malignant thyroid lesions including 36 follicular adenomas (FA), 77 colloid goitres, 26 papillary thyroid carcinomas (PTC) and 9 follicular carcinomas (FC). The results were scored semiquantitatively by staining intensity (0-3 scale) and percentage of positive cells. PTC was characterised by decreased E-CAD and CD56 expression in contrast to surrounding benign thyroid tissues. HBME-1 expression was absent in benign thyroid tissues but was notably high in PTC and occasionally in FC. The expression of E-CAD and CD56 in FA was significantly higher than in the surrounding thyroid tissues. No expression of p53 was found in any group. The expression of COX-2 was low in all lesions. The proliferation activity by Ki-67 was generally low; however, it was significantly higher in cancers. The panel consisting of three markers, HBME-1, E-CAD and CD56, can be recommended as an adjunct to morphology criteria. HBME-1 is found i...Continue Reading

References

Sep 1, 1992·Clinical and Experimental Immunology·J ZeromskiG Dworacki
Apr 1, 1993·The American Journal of Surgical Pathology·Y DobashiR Machinami
Nov 1, 1996·Virchows Archiv : an International Journal of Pathology·M Miettinen, P Kärkkäinen
Jan 6, 1997·International Journal of Cancer. Journal International Du Cancer·P SoaresM Sobrinho-Simões
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Michelle C SpechtThomas J Fahey
Mar 13, 2002·The Laryngoscope·Anthony J CornettaJay L Rothstein
Apr 10, 2002·Clinical Endocrinology·Bryan R HaugenMichael T McDermott
Feb 8, 2003·International Journal of Surgical Pathology·P SmythE C Sweeney
Apr 15, 2003·Journal of Korean Medical Science·Ho-Sung YoonJoo-Ryung Huh
Apr 26, 2003·Histopathology·Y ItoA Miyauchi
Jun 14, 2003·Endocrine Journal·Takahiro MaseAkimasa Nakao
Jul 5, 2003·Cancer Science·Setsuo Hirohashi, Yae Kanai
Dec 18, 2003·Clinical Endocrinology·Duncan Topliss
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·David J FinleyThomas J Fahey
Jul 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Manju L PrasadRichard T Kloos
Nov 6, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Mauro PapottiJuan Rosai
May 26, 2005·Archives of Pathology & Laboratory Medicine·Denise M Haynik, Richard A Prayson
Sep 26, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michel R NasrAnna-Luise A Katzenstein
Nov 30, 2006·Journal of Surgical Oncology·Ronald A DeLellis
Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Hossein Gharib, Enrico Papini
Jul 12, 2008·Diagnostic Cytopathology·Min-En NgaMarian Priyanthi Kumarasinghe
Oct 7, 2008·World Journal of Surgery·Naomi MoritaHiroshi Takami
Feb 25, 2009·The American Journal of Forensic Medicine and Pathology·Dina El DemellawySalem Alowami

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Citations

Aug 17, 2010·Langenbeck's Archives of Surgery·Bruno Niederle
Mar 6, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yoshio OtaKumiko Ogawa
Aug 15, 2012·Diagnostic Pathology·Leandro Luongo de MatosMaria Aparecida da Silva Pinhal
Mar 25, 2014·Pathology Oncology Research : POR·Hanan AlSaeid Alshenawy
Jul 22, 2014·Pathology, Research and Practice·Samar M Abd-El Raouf, Taiseer R Ibrahim
Sep 7, 2018·Journal of Immunoassay & Immunochemistry·Asmaa Gaber AbdouSara Fahmy

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