Diagnostic utility of NT-proBNP and ANP in a canine model of chronic embolic pulmonary hypertension

The Veterinary Journal
Yasutomo HoriFumio Hoshi

Abstract

The information needed to diagnose pulmonary arterial hypertension (PAH) in dogs based on N-terminal pro B-type natriuretic peptide (NT-proBNP) and atrial natriuretic peptide (ANP) levels is unclear. In this study, serial changes in plasma NT-proBNP and ANP concentrations were evaluated in association with the development of chronic embolic pulmonary hypertension (CEPH). Six Beagle dogs underwent percutaneous pulmonary artery catheterization. CEPH was induced by the repeated injection of 300 μm microspheres into the pulmonary artery via the catheter. Measured peak systolic pulmonary arterial pressure (PAPs) was elevated up to 80 mm Hg at 90 days by repeated injection of microspheres. Echocardiographic examination showed significant increase in the main pulmonary artery enlargement, right ventricular dilation, transtricuspid late diastolic flow, and ventricular late diastolic myocardial velocity. Plasma concentrations of NT-proBNP and ANP were significantly increased by microsphere-induced severe CEPH, but not by mild CEPH. Measured PAPs correlated weakly with plasma NT-proBNP and ANP concentrations (r=0.63 and 0.69, respectively) and with several echocardiographic variables. Our results indicated that plasma ANP and NT-proBNP r...Continue Reading

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Citations

Dec 4, 2014·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·James W SwannDavid J Connolly
Apr 30, 2015·The Veterinary Journal·Shinya FukumotoTsuyoshi Uchide
Jun 6, 2020·Veterinary Research Communications·Mizuki OgawaNaoyuki Takemura
Oct 17, 2014·The Journal of Veterinary Medical Science·Shoma MikawaNaoyuki Takemura
Jan 29, 2019·Frontiers in Cardiovascular Medicine·Ashley MulchroneNaomi C Chesler
Oct 25, 2017·Veterinary World·Gabriela Vieira de Lima, Felipp da Silveira Ferreira

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