Abstract
Overlapping morphological characteristics pose some difficulties in making a proper diagnosis of clear cell renal cell carcinoma (CCRCC), chromophobe renal cell carcinoma (ChRCC), and oncocytoma, on the basis of hematoxylin-eosin-stained tissue sections. Our objective was to find out a fast, reliable panel of immunohistochemical markers for differentiation between them. The study was carried out on 55 selected renal tumor specimens: 36 cases of CCRCC, seven cases of ChRCC, and 12 cases of oncocytoma. The specimens were stained immunohistochemically for vimentin, CD117, cytokeratin (CK)7, and caveolin (Cav)-1. Sensitivity and specificity for each marker were calculated. Vimentin expression was exclusively observed in CCRCC (100%) and negative in ChRCC and oncocytoma. CD117 was absent in CCRCC, but it was strongly expressed in ChRCC (85.5%) and oncocytoma (91.7%), with high sensitivity and specificity. Most CCRCCs and oncocytomas were negative for CK7 (91.7% and 83.3%, respectively), in contrast to ChRCCs, which showed positivity in nearly 86% of the cases. Good sensitivity and specificity were calculated for CK7 in differentiating studied oncocytic tumors. Cav-1 was positive in ~78% of the CCRCCs and in all ChRCCs, whereas the v...Continue Reading
References
Jan 1, 1997·The American Journal of Surgical Pathology·M B AminG M Farrow
Aug 1, 1997·The American Journal of Surgical Pathology·B Perez-OrdonezV E Reuter
Jun 6, 2002·Histopathology·Marie E MathersM O'Donnell
Jul 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sang Ling WuJohn H Connelly
Aug 10, 2002·Annals of Diagnostic Pathology·Sang Ling WuRhonda L Shannon
Feb 14, 2003·Oncogene·Ken YamazakiSetsuo Hirohashi
Mar 5, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Mi-Kyung Kim, Seonwoo Kim
Apr 30, 2003·The American Journal of Surgical Pathology·John C ChevilleMichael L Blute
Jun 18, 2003·Urologic Oncology·Rafael CarrionMichael B Morgan
Sep 27, 2003·BMJ : British Medical Journal·Tze-Wey Loong
Apr 24, 2004·The American Journal of Surgical Pathology·Anna PetitCarme Mallofré
Apr 29, 2004·Journal of Clinical Pathology·D MiliarasD Sioutopoulou
Jul 6, 2004·Clinical Biochemistry·Vivian BarakRoland Einarsson
Dec 1, 2004·Histopathology·N A AbrahamsS K Tickoo
Jan 22, 2005·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Feb 16, 2005·Human Pathology·Peter R MazalMartin Susani
Mar 2, 2005·Annales de pathologie·Céline BazilleMathilde Sibony
Apr 16, 2005·The American Journal of Surgical Pathology·Huan-You Wang, Stacey E Mills
Aug 6, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Markku Miettinen, Jerzy Lasota
Nov 15, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Srinivasa R PrasadKedar N Chintapalli
Jun 15, 2007·Journal of Clinical Pathology·Th Van der Kwast, B Perez-Ordoñez
Jun 28, 2007·Cancer·Ila TamaskarMing Zhou
Apr 11, 2008·Journal of Cellular and Molecular Medicine·Andrew F G QuestVicente A Torres
Aug 6, 2008·Der Urologe. Ausg. A·A J SchraderR Hofmann
Sep 25, 2008·The American Journal of Surgical Pathology·Mahul B AminHolger Moch
Jun 30, 2009·Diagnostic Pathology·Dinesh PradhanKusum Joshi
Jun 4, 2011·Cellular and Molecular Life Sciences : CMLS·Arun Satelli, Shulin Li
Dec 14, 2011·BMC Urology·Sandra SteffensJürgen Serth
Jun 22, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Francisco Emilio Vera-BadilloIgnacio Duran