PMID: 3762017Aug 1, 1986Paper

Diagnostic validity of CEA determination in metastasizing breast cancer

Klinische Wochenschrift
G KriegerG A Nagel

Abstract

The diagnostic validity of serial CEA determinations in metastatic breast cancer was investigated. First, the CEA values within 8 weeks after start of therapy were correlated with the response to therapy. Second, the CEA levels were used to predict progression after remission or stable disease. These investigations were performed in 150 patients with advanced breast cancer who had clinical follow-ups and serial CEA determinations every one to three months. CEA was not useful for monitoring response to therapy (sensitivity 63%, specifity 58%) or prediction of relapse (sensitivity 61%, specifity 82%) if CEA levels were correlated with clinical course in all patients. However, diagnostic validity of CEA was achieved if the patients were selected and appropriate definitions of significant changes in CEA used. Thus, 83% of the responders (sensitivity) could be identified by a significant decrease of CEA titers in patients with CEA levels of greater than or equal to 10 ng/ml. A decrease of more than 10% of pretreatment levels during the first 4-8 weeks after start of therapy proved to be the appropriate definition of a significant decrease of CEA titers. However, 32% of the nonresponders were misclassified as responders (unspecifity)...Continue Reading

References

Sep 1, 1978·Cancer·D C Tormey, T P Waalkes
Sep 1, 1982·British Journal of Cancer·H Tate

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Citations

Jan 1, 1991·Cancer Immunology, Immunotherapy : CII·J F RobertsonA Howell

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