Diagnostic value of 18F-dihydroxyphenylalanine positron emission tomography for growth hormone-producing pituitary adenoma.

Pituitary
Takafumi TaguchiYoshio Terada

Abstract

A 55-year-old woman with signs of acromegaly was referred to our hospital. Endocrinological examinations showed that she had high levels of growth hormone (GH; 5.54 ng ml(-1); normal range: 0.66-3.68 ng ml(-1)) and insulin-like growth factor-I (IGF-I; 508 ng ml(-1); normal range: 37-266 ng ml(-1)) levels, incomplete suppression of serum GH following a 75-gram oral glucose tolerance test (oGTT; trough GH 3.66 ng ml(-1)), and paradoxical GH responses to a TRH provocation test (peak GH 38.9 ng ml(-1)). Dynamic magnetic resonance imaging (MRI) suggested the presence of an intrasellar mass lesion (5.9 x 2.8 mm) in the left part of her pituitary gland (Fig. 1a, upper panel). F-18 fluorodeoxyglucose (FDG) positron emission tomographic (PET) imaging clearly showed focal but remarkable FDG uptake (Fig. 1a, lower panel), consistent with the localization of the tumor suspected on MRI. The tumor was removed by transsphenoidal surgery. Subsequent histological analysis confirmed the diagnosis of a GH-producing pituitary adenoma. After removal, serum IGF-I levels decreased to a normal range (178 ng ml(-1)), and serum GH was appropriately suppressed during oGTT (trough GH 0.30 ng ml(-1)), suggesting that complete resection was obtained [1]. Wh...Continue Reading

References

Oct 1, 1990·Radiology·B De SouzaG Di Chiro
Oct 18, 2005·European Journal of Nuclear Medicine and Molecular Imaging·B N T TangS Goldman
Nov 27, 2008·The Journal of Clinical Endocrinology and Metabolism·John D CarmichaelShlomo Melmed

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Citations

Sep 6, 2012·Nursing·Ann Crawford, Helene Harris
Aug 29, 2013·Pituitary·Jean-Christophe Maiza, Cedric Revel
May 10, 2013·Clinical Nuclear Medicine·Yuantao HouBing Xing

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