Diagnostic value of AgNOR method in thyroid cytopathology: correlation with morphometric measurements

Diagnostic Cytopathology
T SolymosiL Csanádi

Abstract

A silver staining technique was applied to 51 thyroid smears. The numbers of silver-stained nucleolar organizer regions (AgNORs) were counted, and the mean AgNOR and nuclear area per cell were determined with an image analyzer. The mean AgNOR count per cell was significantly higher in malignant than in benign lesions, but there was a considerable overlap. The mean AgNOR area and the mean SD of the AgNOR area per cell were significantly higher in carcinomas than in benign lesions (P = 10-9 and P = 5 x 10-10, respectively) and there were only two and one benign cases, respectively, of overlap. A strong correlation was observed between the mean AgNOR area and the mean nuclear area (r = 0.88), the former being a better discriminator between benign and malignant lesions. The AgNOR technique may contribute to routine thyroid cytopathology.

References

Jan 1, 1979·Journal of Cancer Research and Clinical Oncology·G L LukácsI Zs-Nagy
Jan 1, 1992·Cytopathology : Official Journal of the British Society for Clinical Cytology·C BayindirS Dervisoğlu
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·P L MingazziniV Marinozzi
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·R MontironiR Alberti
Jan 1, 1991·Virchows Archiv. A, Pathological Anatomy and Histopathology·S DamianiV Eusebi
Jan 1, 1989·The Journal of Pathology·D A BoldyJ G Ayres
Aug 1, 1989·The Journal of Pathology·J RüschoffA Bittinger
Mar 1, 1989·Human Pathology·R A AmbrosW C Lambert
Oct 1, 1988·Journal of Clinical Pathology·E R NairnJ McGovern
Apr 1, 1985·Diagnostic Cytopathology·S R KiniM J Smith-Purslow

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Citations

Jul 23, 2003·Cytopathology : Official Journal of the British Society for Clinical Cytology·D Słowińska-KlenckaA Lewiński
Jul 14, 2012·Pathology Research International·Mohammad Ismail HossainZillur Rahman
Oct 12, 2012·Pathology Oncology Research : POR·Hayam A AiadAhmad A Zahran

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