Diagnostic value of brain MRI and 18F-FDG PET in the differentiation of Parkinsonian-type multiple system atrophy from Parkinson's disease

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
K-Y KwonS J Chung

Abstract

Differentiation between parkinsonian type multiple system atrophy (MSA-P) and Parkinson's disease (PD) is important but often difficult. We investigated the diagnostic value of brain magnetic resonance imaging (MRI) and (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) in differentiating MSA-P from PD. Twenty-four patients with MSA-P (16 probable and 8 possible) and eight patients with PD were included in this study. For analysis using the putaminal findings, the sensitivities were 58.3% by visual analysis of brain MRI, 95.8% by visual analysis of (18)F-FDG PET, and 79.2% by statistical parametric mapping (SPM) analysis of (18)F-FDG PET in differentiating MSA-P from PD; the specificity was 100% for each analysis. Using the putaminal findings, visual analysis of (18)F-FDG PET had a higher sensitivity compared with brain MRI (P = 0.004) and SPM analysis of (18)F-FDG PET revealed a tendency towards higher sensitivity compared with brain MRI (P = 0.063). For analysis using both putaminal and infratentorial findings, the sensitivities were 79.2% by visual analysis of brain MRI, 95.8% by visual analysis of (18)F-FDG PET, 95.8% by SPM analysis of (18)F-FDG PET in differentiating MSA-P from PD; the specificity was 1...Continue Reading

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Citations

Jan 29, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Chrissa SiokaAthanassios P Kyritsis
Feb 3, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A H V Schapira
Aug 1, 2009·Future Medicinal Chemistry·Boyenoh Gaye, Adeboye Adejare
Oct 1, 2009·Journal of Movement Disorders·Juha O Rinne
Jul 28, 2016·Movement Disorders Clinical Practice·Han-Joon KimVictor S C Fung
Jul 14, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Hirohisa WatanabeGen Sobue
Dec 11, 2013·Clinical Nuclear Medicine·Ümit Özgür AkdemirLütfiye Özlem Kapucu
Jul 30, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Flavia Niccolini, Marios Politis
Sep 20, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Hae Won KimChong Sik Lee

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