Diagnostic value of C-reactive protein for predicting activity level of Crohn's disease

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Patrick ChamouardRené Baumann

Abstract

Measuring Crohn's disease (CD) activity is useful in clinical trials as well as in clinical practice, but each available instrument to measure such activity has some limitations. C-reactive protein (CRP) is a sensitive marker for inflammation and tissue injury. The aims of the study were: to assess the diagnostic value of low level of CRP for predicting a low CD activity, and to calculate optimal CRP cutoff value for selecting patients with moderate or high CD activity. One hundred fifty consecutive patients with active or nonactive CD were included in the study without any pre-selection criteria. CRP was measured, and CD activity was calculated by means of the van Hees index (VHI). The median VHI score was 154.4 (interquartile range, 126.0-193.4), and the median CRP was 19.1 mg/L (interquartile range, 6.1-50.1 mg/L; upper limit of normal [N], 4 mg/L). Forty-nine percent of our patients had CRP >20 mg/L. CRP was significantly correlated to VHI (P = .0001). The probability that VHI was <150 if CRP was below upper limit of normal was equal to 1 (confidence interval, 0.891-1.000). The diagnostic value for CRP predicting a VHI > or =150 was high; the area under the receiver operating characteristic curve was equal to 0.844 (confide...Continue Reading

References

Apr 1, 1980·Gut·P A van HeesJ H van Tongeren
Jun 1, 1996·Gut·S P TravisD P Jewell
Apr 9, 2004·The New England Journal of Medicine·Alan R Tall
Oct 9, 2004·Inflammatory Bowel Diseases·Séverine VermeirePaul Rutgeerts
Sep 7, 2005·Gastroenterology·Stefan SchreiberUNKNOWN CDP870 Crohn's Disease Study Group

❮ Previous
Next ❯

Citations

Jan 30, 2010·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Richard James MairAnne Weaver
Jan 8, 2008·World Journal of Gastroenterology : WJG·Chantal L KoelewijnBas Oldenburg
Apr 9, 2013·Journal of Crohn's & Colitis·Pavol PapayRemo Panaccione
Dec 1, 2008·Journal of Crohn's & Colitis·Nitsan MaharshakIris Dotan
Apr 17, 2007·Digestive Diseases and Sciences·Alexander D Rodgers, Adrian G Cummins
Oct 16, 2009·Digestive Diseases and Sciences·Samantha TilakaratneAndrew S Day
Feb 25, 2015·Autoimmunity·Jacek KarczewskiZygmunt Adamski
Apr 10, 2014·Journal of Crohn's & Colitis·William J SandbornRemo Panaccione
Sep 2, 2016·Nature Reviews. Gastroenterology & Hepatology·Alissa J WalshSimon P L Travis
Oct 6, 2016·Expert Review of Clinical Immunology·Maureen C TurinaDominique Baeten
Feb 15, 2018·Acta Medica (Hradec Králové)·Paula MorávkováJan Bureš
Apr 27, 2018·European Journal of Gastroenterology & Hepatology·Ioannis V MitselosDimitrios K Christodoulou
Jun 25, 2009·The American Journal of Gastroenterology·Franca ViolaSalvatore Cucchiara
May 3, 2018·Inflammatory Bowel Diseases·Christopher J MoranHarland S Winter
Dec 18, 2013·Scandinavian Journal of Gastroenterology·Darina KohoutovaJan Bures
Jul 21, 2015·Journal of Pediatric Gastroenterology and Nutrition·Katalin E MüllerUNKNOWN Hungarian Pediatric IBD Registry Group
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Christopher MaBrian Gordon Feagan
Jul 6, 2019·Journal of Immunology Research·Devis BenfaremoArmando Gabrielli
Jul 12, 2019·Journal of the Canadian Association of Gastroenterology·Md Sharif ShajibWaliul I Khan
Mar 19, 2014·Expert Review of Gastroenterology & Hepatology·Fernando MagroPaula Ministro
Sep 23, 2016·Clinical Medicine Insights. Gastroenterology·Maria Cappello, Gaetano Cristian Morreale
May 1, 2021·International Journal of Molecular Sciences·Ewa ŻyłaJoanna Gromadzka-Ostrowska
Oct 20, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Mahnaz Fatahzadeh
Jun 5, 2007·Pediatrics·David R MackUNKNOWN Pediatric Inflammatory Bowel Disease Collaborative Research Group

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here