Jan 1, 1987

Diagnostic value of cerebrospinal fluid myelin basic protein in patients with neurological illness

Clinical and Experimental Neurology
L DaviesW J Hensley


The levels of myelin basic protein (MBP) in the cerebrospinal fluid (CSF) have been evaluated as a method of detecting central nervous system (CNS) demyelination. MBP levels were measured in the CSF of 129 patients with neurological illnesses of whom 26 had a demyelinating illness. High levels of MBP were found in 81% of patients with recent episodes of demyelination but were not seen in patients with multiple sclerosis that was clinically stable or in remission. Patients with CNS trauma also had high levels of MBP in their CSF. The detection of a high level of MBP in CSF may be useful in the diagnosis of acute CNS demyelination but the finding is not specific for multiple sclerosis.

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Mentioned in this Paper

Chronic Disease
Differential Diagnosis
Clinically Isolated Syndrome, CNS Demyelinating
Myelin Basic Protein, Isoform 4
CNS Disorder
Demyelinating Diseases
Demyelinating Autoimmune Diseases, CNS
Multiple Sclerosis, Acute Fulminating
Multiple Sclerosis
Hereditary Central Nervous System Demyelinating Diseases

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