Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries: a systematic review.

Lancet
Ann Van den BruelEuropean Research Network on Recognising Serious Infection investigators

Abstract

Our aim was to identify which clinical features have value in confirming or excluding the possibility of serious infection in children presenting to ambulatory care settings in developed countries. In this systematic review, we searched electronic databases (Medline, Embase, DARE, CINAHL), reference lists of relevant studies, and contacted experts to identify articles assessing clinical features of serious infection in children. 1939 potentially relevant studies were identified. Studies were selected on the basis of six criteria: design (studies of diagnostic accuracy or prediction rules), participants (otherwise healthy children aged 1 month to 18 years), setting (ambulatory care), outcome (serious infection), features assessed (assessable in ambulatory care setting), and sufficient data reported. Quality assessment was based on the Quality Assessment of Diagnostic Accuracy Studies criteria. We calculated likelihood ratios for the presence (positive likelihood ratio) or absence (negative likelihood ratio) of each clinical feature and pre-test and post-test probabilities of the outcome. Clinical features with a positive likelihood ratio of more than 5.0 were deemed red flags (ie, warning signs for serious infection); features w...Continue Reading

References

Sep 1, 1992·Clinical Pediatrics·M OffringaJ Lubsen
Jan 1, 1991·Archives of Disease in Childhood·C J MorleyT J Cole
Mar 1, 1995·Archives of Pediatrics & Adolescent Medicine·J A TaylorW Winters
Nov 11, 1993·The New England Journal of Medicine·M D BakerJ R Avner
Jun 1, 1996·European Journal of Pediatrics·R M BergerG Derksen-Lubsen
Nov 16, 1996·BMJ : British Medical Journal·F A RiordanC A Hart
Apr 24, 2001·Archives of Disease in Childhood·K ArmonS Smith
Jul 24, 2001·Archives of Disease in Childhood·H E NielsenK Olofsson
Aug 23, 2001·Archives of Disease in Childhood·L C WellsN Rutter
Mar 1, 2002·The Journal of Infection·Z NademiA J Cant
Jun 29, 2005·Acta Paediatrica·Sudhin ThayyilIan G Verber

❮ Previous
Next ❯

Citations

Jan 31, 2012·Primary Health Care Research & Development·Andrew MitraGwen Baxter
May 28, 2011·The New England Journal of Medicine·Kathryn MaitlandUNKNOWN FEAST Trial Group
Nov 26, 2010·Family Practice·Yvette van IerlandHenriëtte A Moll
Feb 6, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·E BottieauJ Jacobs
Apr 21, 2012·Current Opinion in Critical Care·Michel E van GenderenAlexandre Lima
Sep 22, 2012·Pediatric Dermatology·Paul L AronsonSamir S Shah
Jan 27, 2011·Archives of Disease in Childhood·Andrew J BrentRoddy MacFaul
Sep 28, 2012·BMJ : British Medical Journal·Ann Van den BruelDavid Mant
May 21, 2013·Postgraduate Medical Journal·Damian Roland
May 18, 2011·BMC Family Practice·Gijs ElshoutMarjolein Y Berger
Jan 4, 2013·BMC Family Practice·Christiaan F StolperGeert Jan Dinant
Jan 17, 2013·BMC Medicine·Jan Y VerbakelUNKNOWN European Research Network on Recognising Serious Infection (ERNIE)
Apr 27, 2011·Anesthesia and Analgesia·Amelia PickardJ Mark Ansermino
Mar 19, 2014·PloS One·Evelien KerkhofUNKNOWN European Research Network on recognising serious InfEctions (ERNIE) members
Mar 16, 2011·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Frank BuntinxGeert-Jan Dinant
Dec 26, 2012·The British Journal of General Practice : the Journal of the Royal College of General Practitioners·Claire BlacklockMatthew J Thompson
Nov 15, 2013·Archives of Disease in Childhood. Education and Practice Edition·David KingCliff Bevan
Sep 12, 2014·Lancet·Stavros PetrouPeter Sidebotham
Sep 19, 2014·Medical Teacher·Abhishek Biswas
Jun 8, 2012·Paediatric Anaesthesia·Ellen Rawlinson, Oliver Bagshaw
Jan 14, 2016·Archives of Disease in Childhood·Ann Van den BruelDavid Mant
Oct 10, 2013·Journal of Clinical Nursing·Edward Purssell
Apr 12, 2016·Journal of Paediatrics and Child Health·Mike Starr
Apr 12, 2016·Journal of Paediatrics and Child Health·Damian RolandFfion Davies
Oct 15, 2013·Journal of Evaluation in Clinical Practice·Mohamed A ElemraidUNKNOWN North East of England Paediatric Respiratory Infection Study Group
Jul 17, 2015·Pediatric Emergency Care·Ruud G NijmanRianne Oostenbrink
Nov 17, 2011·Expert Review of Vaccines·Marco A P Sáfadi, E David G McIntosh
Dec 3, 2014·Annals of Emergency Medicine·Samuel VaillancourtMichael J Schull
Jan 12, 2013·Journal of Clinical Epidemiology·Bart SpruijtRianne Oostenbrink
Sep 5, 2014·Advances in Health Sciences Education : Theory and Practice·C F StolperG J Dinant
Sep 28, 2014·Archives of Disease in Childhood·Susannah FlemingMatthew Thompson
Nov 15, 2012·The Journal of Pediatrics·Yvette van IerlandRianne Oostenbrink
Jun 20, 2014·European Journal of Pediatrics·Joris FuijkschotJan L C M Loeffen
Dec 3, 2014·The American Journal of Emergency Medicine·Yu-Che ChangKuang-Hung Hsu
Apr 8, 2016·Hospital Pediatrics·Catherine S ForsterPatrick W Brady

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Meningitis

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.

Bacterial Meningitis (ASM)

Bacterial meningitis continues to be an important cause of mortality and morbidity throughout the world. Here is the latest research.