Diagnostic value of combination serum assay of lactate dehydrogenase, D-dimer, and C-reactive protein for uterine leiomyosarcoma

The Journal of Obstetrics and Gynaecology Research
Yoshiko NishigayaMitsutoshi Iwashita

Abstract

Leiomyosarcoma is the most common type of uterine sarcoma. In some leiomyosarcoma cases, preoperative diagnosis might be difficult, and they might be treated as benign lesions. We evaluated diagnostic values of preoperative serum lactate dehydrogenase (LDH), D-dimer and C-reactive protein for differentiating leiomyosarcoma. From 2008 to 2013, leiomyosarcoma cases in three university hospitals were enrolled. Preoperative serum LDH, D-dimer and C-reactive protein were analyzed if tested. These markers of pathologically diagnosed leiomyoma cases presumed benign (group B) and presumed malignant (group PM) were compared with those of leiomyosarcoma cases (group S). Groups S, PM and B had 36, 28 and 69 cases, respectively. Positive rates of LDH were 66.7%, 14.3% and 0% in groups S, PM and B, respectively. Positive rates of D-dimer and C-reactive protein were 83.3% and 64.5%, 17.9% and 10.7% and 5% and 2.9% in groups S, PM and B, respectively. Positive rates of all three markers were high in the order of leiomyosarcoma, atypical leiomyoma and typical leiomyoma. In group PM, 12 (63.2%) cases were negative for all three markers, whereas 1 (3.3%) case was negative in group S. No case was positive for all markers in group PM, whereas 41.2...Continue Reading

References

Jan 1, 1992·Gynecologic and Obstetric Investigation·K SekiI Nagata
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Jul 30, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·A GotoT Maruo
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Nov 3, 2011·BMC Musculoskeletal Disorders·Takeshi MoriiKazuhiko Satomi
Jun 27, 2012·AJR. American Journal of Roentgenology·Shaan H ShahNikhil H Ramaiya
Dec 26, 2013·American Journal of Obstetrics and Gynecology·Kenichiro SatoYasuyoshi Fukushima
Dec 19, 2015·Journal of Minimally Invasive Gynecology·P G PaulAditya S Khurd
Dec 25, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ana M RodriguezGokhan S Kilic
Dec 21, 2016·Journal of Computer Assisted Tomography·Hai Ming LiFengHua Ma
Mar 21, 2017·Gynecologic Oncology·Brandon-Luke L SeagleShohreh Shahabi
Sep 12, 2017·The Journal of Obstetrics and Gynaecology Research·Toshiaki SaitoUNKNOWN 2016 Committee on Gynecologic Oncology of the Japan Society of Obstetrics and Gynecology
Oct 19, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Klaus PietznerKlaus Kraywinkel

❮ Previous
Next ❯

Citations

Dec 11, 2019·BMJ Case Reports·Benita KnoxAlex Ades
Jan 31, 2020·Current Oncology Reports·Christine De BruynAn Coosemans
Nov 17, 2020·Journal of Computer Assisted Tomography·Philip H CoffinJames Spies

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.