Diagnostic value of decoy receptor 3 combined with procalcitonin and soluble urokinase-type plasminogen activator receptor for sepsis

Cellular & Molecular Biology Letters
Jing-Jing ZhaoYan-Qiang Hou

Abstract

The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 combined with suPAR and PCT in sepsis. Patients with sepsis, non-infectious systemic inflammatory response comprehensive syndrome (SIRS) and healthy controls were recruited according to the diagnostic standard. We measured DcR3, suPAR, PCT, interleukin-6 (IL-6) and C-reactive protein (CRP), and the diagnostic value was evaluated by receiver operating characteristics (ROC) curves. In our analysis, serum DcR3, suPAR and PCT levels of the sepsis group were significantly higher than those of the SIRS and control groups. However, IL-6, CRP and WBC showed no significant difference between the SIRS group and the sepsis group. The serum DcR3 level was positively correlated with the serum suPAR level (r = 0.37, p = 0.0022) and PCT level (r = 0.37, p = 0.0021). Using DcR3, suPAR and PCT to distinguish SIRS from sepsis, the area under the curve (AUC) values were 0.892, 0.778 and 0.692. When DcR3, suPAR and PCT combined were used for diagnosis of sepsis, the AUC was 0.933, at a cut-off point of 0.342. This combination improved the sen...Continue Reading

References

Apr 13, 1999·Critical Care Medicine·H UgarteJ L Vincent
Jun 29, 1999·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E RuokonenJ Takala
May 17, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sunghee KimVassiliki Kotoula
Apr 24, 2007·Critical Care : the Official Journal of the Critical Care Forum·Fernando A BozzaPatrícia T Bozza
Mar 14, 2008·Current Medicinal Chemistry·I Herzum, H Renz
Feb 11, 2010·Critical Care : the Official Journal of the Critical Care Forum·Charalampos Pierrakos, Jean-Louis Vincent
Apr 12, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·T MölkänenA Järvinen
Oct 4, 2011·Critical Care Medicine·Tara LaguPeter K Lindenauer
Jan 10, 2012·BMC Medicine·Katia DonadelloJean-Louis Vincent
Jan 28, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yan-Qiang HouSunghee Kim
Jun 1, 2012·Diagnostic Microbiology and Infectious Disease·Sunghee KimLurong Zhang
Jan 9, 2013·Brain, Behavior, and Immunity·T Michael O'SheaUNKNOWN ELGAN Study Investigators
Jan 31, 2013·Intensive Care Medicine·R P DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup
Feb 5, 2013·The Lancet Infectious Diseases·Christina WackerPeter Schlattmann
Dec 18, 2013·Virulence·Frank Bloos, Konrad Reinhart
May 7, 2014·BioMed Research International·Cesar Henriquez-Camacho, Juan Losa
Sep 26, 2015·Innate Immunity·Samira KhakpourJudith Hellman
Oct 18, 2015·Journal of Critical Care·Hoi-Ping ShumTak Mao Chan
Feb 26, 2016·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Ming-Han ChenShie-Liang Hsieh
Jun 21, 2017·Journal of Biomedical Science·Shie-Liang Hsieh, Wan-Wan Lin

❮ Previous
Next ❯

Citations

May 1, 2019·The Cochrane Database of Systematic Reviews·Daniel Molano FrancoJavier Zamora
Jul 19, 2019·BioMed Research International·Su LinJianhua Lin
Mar 14, 2020·Micromachines·Andrew TeggertZulfiqur Ali
Dec 29, 2020·Frontiers in Immunology·Yulia KiyanNelli Shushakova

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
PCT

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.