PMID: 5919361Sep 1, 1966

Diagnostic value of detailed metabolic pathway investigations in two cases of phaeochromocytoma with minimal increase in total catecholamine output

Journal of Clinical Pathology
J J BrownM SANDLER

Abstract

Two patients with phaeochromocytoma having atypical biochemical features are described. Total catecholamine excretion was normal in one and only slightly raised in the other; both had a diagnostic rise in output of metadrenaline and 4-hydroxy-3-methoxymandelic acid whilst 4-hydroxy-3-methoxyphenylglycol excretion was increased in one of them. During hypertensive attacks adrenaline excretion became greater than that of noradrenaline. The diagnostic usefulness of separate adrenaline and noradrenaline estimations in addition to catecholamine metabolite assay is discussed. A lack of relationship between tumour catecholamine content and urinary catecholamine output is emphasized.

References

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Citations

Aug 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M Gutteridge

Related Concepts

Catecholamines
Medihaler-Epi
Mandelic Acids
Norepinephrine, (+, -)-Isomer
Pheochromocytoma, Extra-Adrenal

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