PMID: 5919361Sep 1, 1966

Diagnostic value of detailed metabolic pathway investigations in two cases of phaeochromocytoma with minimal increase in total catecholamine output

Journal of Clinical Pathology


Two patients with phaeochromocytoma having atypical biochemical features are described. Total catecholamine excretion was normal in one and only slightly raised in the other; both had a diagnostic rise in output of metadrenaline and 4-hydroxy-3-methoxymandelic acid whilst 4-hydroxy-3-methoxyphenylglycol excretion was increased in one of them. During hypertensive attacks adrenaline excretion became greater than that of noradrenaline. The diagnostic usefulness of separate adrenaline and noradrenaline estimations in addition to catecholamine metabolite assay is discussed. A lack of relationship between tumour catecholamine content and urinary catecholamine output is emphasized.


Mar 1, 1966·Postgraduate Medical Journal·J J BrownA D Wright
Apr 1, 1953·British Heart Journal·M HAMILTONG S C SOWRY
Jan 1, 1952·Scandinavian Journal of Clinical and Laboratory Investigation·A LUND
Jan 1, 1956·Scandinavian Journal of Clinical and Laboratory Investigation·I FLODING, U S VON EULER
Jan 1, 1959·The Journal of Clinical Investigation·A SJOERDSMAS UDENFRIEND
Jan 15, 1959·Klinische Wochenschrift·O KRAUPPH OBENAUS
Mar 1, 1961·American Heart Journal·J R CROUTA SJOERDSMA
Oct 1, 1960·Circulation·J R CROUT, A SJOERDSMA
May 1, 1961·Circulation Research·S E GITLOWS KHASSIS
Mar 1, 1961·The Journal of Clinical Endocrinology and Metabolism·S L JACOBSR J HENRY
Jul 1, 1961·The Biochemical Journal·M SANDLER, C R RUTHVEN
Mar 31, 1959·Acta Physiologica Scandinavica·U S VON EULER, F LISHAJKO
Jan 1, 1960·The Journal of Clinical Investigation·S E GITLOWJ SHA
Jan 1, 1964·The Journal of Clinical Investigation·J R CROUT, A SJOERDSMA
Jul 1, 1964·Journal of Clinical Pathology·J KELLEHERP SMITH
Nov 7, 1964·Lancet·L R GJESSING, I HJERMANN
May 1, 1965·Journal of Clinical Pathology·E D WILLIAMS
May 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J PISANO
May 19, 1962·British Medical Journal·H M LEATHERR M WALKER
Mar 1, 1962·Clinica Chimica Acta; International Journal of Clinical Chemistry·J J PISANOD ABRAHAM
Jan 1, 1962·Clinica Chimica Acta; International Journal of Clinical Chemistry·R ROBINSON, P SMITH
Sep 23, 1950·Lancet·A ENGEL, U S VON EULER
May 1, 1951·The American Journal of Medicine·M GOLDENBERG
Mar 1, 1951·British Journal of Pharmacology and Chemotherapy·T B B CRAWFORD, A S OUTSCHOORN
Apr 25, 1951·Acta Physiologica Scandinavica·U S VON EULER, S HELLNER


Aug 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·J M Gutteridge

Related Concepts

Mandelic Acids
Norepinephrine, (+, -)-Isomer
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