Diagnostic value of diffusion-weighted magnetic resonance imaging for local and skull base recurrence of nasopharyngeal carcinoma after radiotherapy

Medicine
Chen WangNingbin Luo

Abstract

Tumor recurrence is a major cause of nasopharyngeal carcinoma (NPC) treatment failure. Diffusion-weighted imaging (DWI) is used for a variety of cancers, but few data are available for NPC.The aim of the study was to investigate the DWI features of recurrent NPC after radiotherapy and apparent diffusion coefficient (ADC) thresholds for the diagnosis of recurrent NPC.This was a retrospective study of 160 patients with NPC treated by radiotherapy at the Cancer Hospital affiliated to Guangxi Medical University from May 2012 to March 2015. The patients were divided into the local recurrence (n = 39), fibrosis (n = 51), clivus recurrence (n = 22), and clivus nonrecurrence (n = 48) groups. The patients underwent magnetic resonance imaging (MRI), enhanced MRI, and DWI. Receiver operating characteristics curves were used to determine sensitivity, specificity, and negative predictive values.ADC values were significantly different between the recurrence and fibrosis groups (P < .0001). Using ADC threshold values of 0.887 × 10 mm/s for local recurrence, the area under the curve (AUC) of DWI was 0.967 (87.2% sensitivity and 94.1% specificity), compared with 0.732 for routine MRI (71.8% sensitivity and 74.5% specificity) (P < .001). Using A...Continue Reading

References

May 10, 2000·International Journal of Radiation Oncology, Biology, Physics·M AltunR Meral
Jun 14, 2005·Lancet·William I Wei, Jonathan S T Sham
Aug 16, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Shu-Hang NgCheng-Lung Hsu
Jun 13, 2009·Current Molecular Medicine·Sara RockwellVan Thuc Vu
Aug 21, 2009·Investigative Radiology·Peter GibbsLindsay W Turnbull
Jan 5, 2010·Journal of Neurology·Jaume RoquerA Ois
May 22, 2010·AJNR. American Journal of Neuroradiology·K M SchwartzB A Neff
Sep 14, 2010·Medical Physics·Matthew P LarocqueB Gino Fallone
May 25, 2012·AJR. American Journal of Roentgenology·Daniel T GinatSven Ekholm
Jun 14, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Jun HanYongan Gao
Dec 12, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Ikuko UwanoAkira Ogawa
Mar 16, 2013·Journal of Computer Assisted Tomography·Guanqiao JinXiang Yang Huang
Jul 26, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jinsheng HongJianji Pan
Aug 21, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D GenovesiA R Cotroneo
Mar 19, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Maarten LambrechtSandra Nuyts
Jul 24, 2014·AJR. American Journal of Roentgenology·Aravind MohandasRathan M Subramaniam
Oct 13, 2015·European Journal of Radiology·Zhaoqin HuangJianjun Xiu
Nov 7, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Huijun ZhouLin Li

❮ Previous
Next ❯

Citations

Apr 28, 2021·Magnetic Resonance Imaging Clinics of North America·Felix BoucherAshok Srinivasan
Jun 21, 2021·Seminars in Ultrasound, CT, and MR·Claudia F Kirsch, Mai-Lan Ho

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy
imaging technique

Software Mentioned

SPSS
MedCalc

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.