Diagnostic Value of Diffusion-Weighted MRI for Tumor Characterization, Differentiation and Monitoring in Pediatric Patients with Neuroblastic Tumors

RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
Henning NeubauerM Beer

Abstract

Purpose We explored the diagnostic value of diffusion-weighted MRI (DWI) for tumor characterization, differentiation and therapy monitoring in pediatric patients with extracranial neuroblastic tumors. Materials and Methods All 29 patients (14 girls, median age: 3 years) with neuroblastoma (NB, n = 19), ganglioneuroblastoma (GNB, n = 4) and ganglioneuroma (GN, n = 6) who had had at least one in-house DWI examination since 2005 were identified and retrospectively analyzed. Two independent blinded readers measured ADC values (unit: 10-3 mm(2)/s) and signal intensity ratios (SIRs) of the primary tumor and, if applicable, of the tumor after chemotherapy, metastases and tumor relapse. Results The pre-treatment ADC was 0.90 ± 0.23 in NB/GNB and 1.70 ± 0.36 in GN without overlap between the two entities for both readers, 0.67 ± 0.14 in metastases and 0.72 ± 0.18 in tumor relapse. With chemotherapy, mean ADC increased to 1.54 ± 0.33 in NB/GNB and to 1.23 ± 0.27 in metastases (p < 0.05). The median SIRs of various tumor lesions vs. liver, vs. muscle tissue and vs. adjacent tissue were significantly higher on DWI (range: 2.4 - 9.9) than on ce-T1w (range: 1.0 - 1.8, all p < 0.05). The coefficient of variation (CV) was ≤ 8.0 % for ADC and ≤...Continue Reading

Citations

Dec 12, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Christian Philipp ReinertSergios Gatidis
Jan 27, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Ravi V GottumukkalaMary-Louise C Greer
Dec 19, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Sebastian GassenmaierJürgen F Schäfer
Jun 23, 2021·Der Radiologe·Friederike Körber, Jürgen Frank Schäfer
Jun 23, 2021·Pediatric Radiology·Jonathan R Dillman, Jean A Tkach
Jun 18, 2021·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Jialei WangYunbo Ma

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