Diagnostic Value of Elevated D-Dimer Level in Venous Thromboembolism in Patients With Acute or Subacute Brain Lesions

Annals of Rehabilitation Medicine
Yeon Jin KimGeun-Young Park

Abstract

To define the risk factors that influence the occurrence of venous thromboembolism (VTE) in patients with acute or subacute brain lesions and to determine the usefulness of D-dimer levels for VTE screening of these patients. Medical data from January 2012 to December 2013 were retrospectively reviewed. Mean D-dimer levels in those with VTE versus those without VTE were compared. Factors associated with VTE were analyzed and the odds ratios (ORs) were calculated. The D-dimer cutoff value for patients with hemiplegia was defined using a receiver operating characteristic (ROC) curve. Of 117 patients with acute or subacute brain lesions, 65 patients with elevated D-dimer levels (mean, 5.1±5.8 mg/L; positive result >0.55 mg/L) were identified. Logistic regression analysis showed that the risk of VTE was 3.9 times higher in those with urinary tract infections (UTIs) (p=0.0255). The risk of VTE was 4.5 times higher in those who had recently undergone surgery (p=0.0151). Analysis of the ROC showed 3.95 mg/L to be the appropriate D-dimer cutoff value for screening for VTE (area under the curve [AUC], 0.63; 95% confidence interval [CI], 0.5-0.8) in patients with acute or subacute brain lesions. This differs greatly from the conventional ...Continue Reading

References

Dec 15, 1994·The New England Journal of Medicine·W H GeertsJ P Szalai
Nov 1, 1996·Archives of Physical Medicine and Rehabilitation·D X CifuB E Wall
Apr 30, 2008·Haematologica·Cristina LegnaniUNKNOWN PROLONG Investigators (FCSA and Italian Federation of Thrombosis Centers)
Nov 5, 2011·Journal of Korean Neurosurgical Society·Young-Woo ParkHa-Young Choi
Feb 12, 2013·Journal of Vascular Surgery·Bala RamananIraklis I Pipinos
May 10, 2013·British Journal of Hospital Medicine·Richard A Armstrong, Jacqueline Taylor
Aug 7, 2013·Journal of Neurosurgery·Julian PrellChristian Strauss
Mar 19, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xin HuMing Liu
Dec 5, 2014·JAMA Surgery·John Y S KimDavid M Mahvi
Dec 10, 2014·North American Journal of Medical Sciences·Swaroopa Pulivarthi, Murali Krishna Gurram
Dec 17, 2014·Journal of Neurosurgery·Kristopher T Kimmell, Babak S Jahromi

❮ Previous
Next ❯

Citations

Apr 14, 2017·World Journal of Gastroenterology : WJG·Masatoshi KochiHideki Ohdan

❮ Previous
Next ❯

Software Mentioned

SAS Enterprise Guide
MMSE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.