Diagnostic Value of FDG PET-CT Quantitative Parameters and Deauville-Like 5 Point-Scale in Predicting Malignancy of Focal Thyroid Incidentaloma

Frontiers in Medicine
Philippe ThuillierRonan Abgral

Abstract

Objective: To evaluate the diagnostic value of FDG PET-CT metabolic parameters and Deauville-like 5 point-scale to predict malignancy in a population of patients presenting focal thyroid incidentaloma (fTI). Design: This retrospective study included 41 fTI, classified according to cytological and histological data as benign (BL) or malignant lesion (ML). FDG PET-CT semi-quantitative parameters (SUVmax, SUVmean, SUVpeak, MTV, TLG), tumor to liver SUVmean ratio (TLRmax and TLRmean), tumor to blood-pool SUVmean ratio (TBRmax and TBRmean) were calculated. Each fTI was also classified on a Deauville-like 5-point scale (DS) currently used in lymphoma. Comparison between BL and ML was performed for each parameter and a ROC analysis was conducted. Results: All quantitative PET metabolic parameters (SUV parameters, volume based parameters and SUV ratio) were higher in ML compared with BL, yet no significant difference was reported. fTI (uptake) malignancy rate according to DS grades 2, 3, 4, and 5 was, respectively, 25% (1 of 4), 28.6% (2 of 7), 8.3% (1 of 12), and 33.3% (6 of 18) with no significant difference between ML and BL groups. Results of ROC analysis showed that mean TBR had the highest AUC in our cohort (0.66 95%CI [0.41; 0.9...Continue Reading

References

Jan 1, 1950·Cancer·W J YOUDEN
Apr 21, 2011·Endocrine·Tsung-Ying HoTzu-Chen Yen
Jul 26, 2012·Thyroid : Official Journal of the American Thyroid Association·Kerstin Kathrine SoelbergLaszlo Hegedüs
Aug 21, 2012·The Journal of Clinical Endocrinology and Metabolism·Francesco BertagnaRaffaele Giubbini
Nov 16, 2012·European Journal of Nuclear Medicine and Molecular Imaging·Christophe Van de WieleAlex Maes
Jan 29, 2013·Clinical Nuclear Medicine·Virendra KumarEdward A Eikman
Nov 8, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Ronan AbgralPierre-Yves Salaün
Jun 27, 2017·Endocrine Connections·Philippe ThuillierPierre-Yves Salaun
Mar 10, 2018·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Huazheng ShiShiyuan Liu
Jul 19, 2018·Clinical Endocrinology·Pierpaolo TrimboliLuca Giovanella

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Citations

Jun 11, 2020·Thyroid : Official Journal of the American Thyroid Association·Luca CerianiLuca Giovanella
Mar 21, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Ronan AbgralPierre-Yves Salaun

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Methods Mentioned

BETA
biopsy

Software Mentioned

XLSTAT®

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