PMID: 3749785Sep 1, 1986Paper

Diagnostic value of ferritin analysis in pleural effusions

Scandinavian Journal of Clinical and Laboratory Investigation
N MilmanF Ravn

Abstract

Ferritin was analysed with an immunoradiometric assay using anti-spleen ferritin antibodies, in pleural effusions (Pl) from 28 patients with malignant effusions (18 carcinoma, 10 mesothelioma), 15 patients with non-malignant exudative effusions of unknown aetiology, and from 12 patients with transudative effusions due to congestive cardiac failure. Geometric mean Pl-ferritin was 617 micrograms/l in carcinoma, 1301 micrograms/l in mesothelioma (p less than 0.01 against carcinoma), 931 micrograms/l in non-malignant exudates, and 178 micrograms/l in transudates (p less than 0.0001 against malignant and non-malignant exudates). There was no correlation between Pl-ferritin and Pl-protein, Pl-albumin or Pl-cell count. P1-ferritin displayed a wide overlap between the various groups, and was of no value in the discrimination between malignant and non-malignant exudates. In the differentiation between exudates and transudates, the diagnostic accuracy of Pl-ferritin was only slightly lower compared to Pl-protein and Pl-albumin. With the present method, analysis of Pl-ferritin appears to be of limited value in the routine diagnostic evaluation of pleural effusions.

References

Nov 1, 1977·The Medical Clinics of North America·R W Light
Feb 1, 1979·American Journal of Clinical Pathology·A O VladutiuF W Brason
Jun 1, 1979·Thorax·L TelviJ Chrétien
May 1, 1975·British Journal of Haematology·L W PowellJ W Drysdale
Feb 1, 1986·Scandinavian Journal of Clinical and Laboratory Investigation·N MilmanN S Pedersen
Sep 1, 1974·British Journal of Haematology·M SummersA Jacobs
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
May 26, 1966·The New England Journal of Medicine·T J Vecchio
Sep 25, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·B M JonesA Jacobs
Sep 1, 1983·British Journal of Haematology·B M JonesA Jacobs

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