Diagnostic value of galectin-3 as a marker for malignancy in follicular patterned thyroid lesions

Head & Neck
Yael Oestreicher-KedemYoram Stern

Abstract

The determination of malignancy in follicular patterned thyroid lesions is based on postoperative histologic findings. Therefore, affected patients are referred for surgery, although only 20% will have a final diagnosis of malignancy. The aim of this study was to investigate the potential of galectin-3 as a marker of malignancy in these lesions. Fifty-four tissue specimens of follicular patterned thyroid lesions were immunohistochemically stained for galectin-3. Area and intensity scores were recorded. Significant differences were found between the benign and malignant lesions. The sensitivity, specificity, positive predictive values, and negative predictive values of galectin-3 staining were 82%, 68%, 75%, and 77%, respectively (p=.0002). Significant differences were also found between the subgroups of benign and malignant lesions (p < or =.05). Galectin-3 staining is highly sensitive for malignancy in follicular patterned thyroid lesions. Diagnostic problems may arise in the presence of Hurthle cell proliferation or minimally invasive follicular carcinoma.

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Citations

Jun 13, 2008·Endocrine Pathology·Stefano Serra, Sylvia L Asa
Mar 4, 2010·Endocrine Pathology·Figen BarutSukru Oguz Ozdamar
Jul 18, 2008·Thyroid : Official Journal of the American Thyroid Association·Sven SaussezGuy Laurent
May 4, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Iman Loay Hussein Abulkheir, Dalia Bilal Mohammad
Aug 15, 2012·Diagnostic Pathology·Leandro Luongo de MatosMaria Aparecida da Silva Pinhal
Jul 22, 2014·Pathology, Research and Practice·Samar M Abd-El Raouf, Taiseer R Ibrahim
Mar 14, 2008·Clinical and Experimental Immunology·E LippertG Rogler
Apr 7, 2010·The American Journal of Pathology·Connie G ChiuSam M Wiseman
Apr 20, 2010·Cancers·Vitaly BalanAvraham Raz
Aug 12, 2017·International Journal of Molecular Sciences·Pierpaolo TrimboliLuca Giovanella
Jan 5, 2018·Endocrine Reviews·Elizabeth J de KosterDennis Vriens
Nov 26, 2008·Virchows Archiv : an International Journal of Pathology·Gülçin YegenMüge Tunçyürek
Nov 24, 2019·Expert Review of Anticancer Therapy·Jennifer LiSam M Wiseman
Jan 1, 2008·Biomarker Insights·Rosaria M RuggeriMaria Trovato
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Sandra Fischer, Sylvia L Asa

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