Diagnostic value of IgM deposition at the dermo-epidermal junction

International Journal of Dermatology
K KulthananP Suthipinittharm

Abstract

Granular immunoglobulin M (IgM) deposits at the dermo-epidermal junction (DEJ) are common in lupus erythematosus (LE); however, weak, interrupted, linear and granular patterns of IgM at the DEJ have been reported in sun-exposed skin in normal adults and in a heterogeneous group of diseases. We analyzed 200 patients with positive IgM direct tissue immunofluorescence deposition at the DEJ, alone or in combination with other immunoreactants, in order to determine the diagnostic significant of IgM deposition at the DEJ. IgM deposition at the DEJ, commonly in combination with other immunoreactants, was associated with LE in 57.5% of patients. In cases with IgM deposition alone at the DEJ, only 12% had LE (strong intensities). IgM deposition at the DEJ was associated with other dermatoses in 42.5% of patients. In non-lupus patients, IgM deposition was the sole finding in 59% of cases, and was weaker and more focal than in LE patients. IgM deposition at the DEJ in patients with LE tends to exhibit a strong intensity and is commonly detected in combination with other immunoreactants. IgM deposition alone at the DEJ, especially of weak intensity or focal in pattern, is noted in non-lupus patients, and has less diagnostic significance.

Citations

Jul 27, 2010·Indian Journal of Dermatology, Venereology and Leprology·Leena ChularojanamontriKanokvalai Kulthanan
Oct 6, 2015·Journal of Cutaneous Pathology·Kinga Cristina SlavescuAdrian Baican
Oct 1, 2016·Indian Journal of Dermatology·Subramanian KumudhiniSathish Pai
Apr 7, 2005·Journal of Cutaneous Pathology·Andrew P KontosDavid P Fivenson
Jan 29, 2020·The American Journal of Dermatopathology·Randie H Kim, Nooshin K Brinster
Dec 19, 2019·Frontiers in Immunology·Anastas PashovEivind Hovig
Jul 29, 2017·Clinical Reviews in Allergy & Immunology·Simone RiberoDan Lipsker
Aug 16, 2012·The American Journal of Dermatopathology·Daniel D Miller, Jag Bhawan

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