Diagnostic Value of Methylated Septin9 for Colorectal Cancer Detection

Frontiers in Oncology
Li XieTianhui Chen

Abstract

Methylated Septin9 (mSEPT9) has been suggested as a reliable biomarker in colorectal cancer (CRC) detection. We aimed to determine the diagnostic value of mSEPT9 for CRC detection in Chinese patients. In addition, we compared the diagnostic efficacy of mSEPT9 to traditional screening method [fecal occult blood test (FOBT)] and two biomarkers [carcinoembryonic antigen (CEA) and carbohydrate antigen-199 (Ca-199)]. Overall 248 subjects including 123 patients with CRC and 125 controls were included. Plasma and fecal samples were collected for CEA, Ca-199, mSEPT9, and FOBT tests. Sensitivity and specificity were calculated to evaluate the diagnostic efficacy of each method; receiver operating characteristic (ROC) curve was plotted for the assessment of diagnostic accuracy, and comparisons among FOBT, mSEPT9, and the combination were assessed through area under the ROC curve (AUC). mSEPT9 achieved overall sensitivity and specificity of 61.8% [95% confidence interval (CI): 53.0-69.9%] and 89.6% (83.0-93.8%), respectively, with an AUC value of 0.757 (95% CI: 0.701-0.807), superior to FOBT [sensitivity: 61.4% (50.9-70.9%); specificity: 70.3% (59.1-79.5%); AUC: 0.658 (0.578-0.723)], CEA [sensitivity: 35.0% (27.1-43.7%); specificity: 62.6...Continue Reading

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Citations

Dec 19, 2019·The American Journal of Gastroenterology·Tobias NiedermaierHermann Brenner
Jul 2, 2020·Cancer Management and Research·Wojciech Jelski, Barbara Mroczko
Feb 28, 2020·World Journal of Gastrointestinal Oncology·Alexandre Loktionov
Apr 25, 2021·Clinical Epigenetics·Yunfeng ZhangJian-Bing Fan
Jan 29, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tobias NiedermaierHermann Brenner

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