Diagnostic value of monitoring kinetics of antibody responses in candidiasis by a solid-phase radioimmunoassay

American Journal of Clinical Pathology
H Mauch

Abstract

A solid-phase radioimmunoassay was used to monitor antibody binding to cytoplasmic antigens of Candida albicans in sera from patients with superficial or deep-seated candidiasis over extended observation periods. Healthy persons showed a constant level of Candida antibodies. Patients with superficial candidiasis or colonization generally had a slow, but significant rise; patients with presumptive and proven systemic candidiasis, however, developed rapid rises (up to forty-fold) of antibody levels within a few days. This method permitted the kinetics of antibody response to be followed and, thus, appeared to aid in the differentiation among the various forms of candidiasis.

Related Concepts

Related Feeds

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.