Diagnostic value of nipple cytology: study of 466 cases

Cancer
Bobbi PrittAbdelmonem Elhosseiny

Abstract

Nipple discharge/scraping cytology is a simple, noninvasive method that complements patient assessment. Despite low reported sensitivities for detecting malignancy, the authors predicted that this method would provide important diagnostic information when applied to patients with nonphysiologic nipple discharge or eczematous nipple lesion. From 1995-2002, 466 case specimens from 395 patients were evaluated by nipple discharge or scraping cytology. Of the 98 patients with abnormal cytologic findings, histologic follow-up was available for 45 cases (39 patients). After review, each case was categorized as negative or positive for malignancy. Cytologic findings were compared with the findings of subsequent biopsy or excision of the affected duct or nipple lesion. Of the 13 cases of in situ or invasive carcinoma diagnosed by histology, 11 had positive cytology (sensitivity, 85%). Two malignant cases were not represented by preceding cytology and one case with positive cytology failed to demonstrate malignancy after a subsequent biopsy was performed (specificity, 97%). Clinically, all but one case of malignancy was associated with a serosanguinous discharge or eczematous nipple lesion. The cytology of all malignant cases showed dysh...Continue Reading

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Citations

Mar 23, 2006·Obstetrical & Gynecological Survey·Aneela N HussainMiriam T Vincent
Nov 4, 2015·Journal de gynécologie, obstétrique et biologie de la reproduction·L Boulanger, J Demetz
Feb 27, 2013·Diagnostic Cytopathology·Toshiro YokoyamaMasayoshi Kage

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