Diagnostic value of nitric oxide, lipoprotein(a), and malondialdehyde levels in the peripheral venous and cavernous blood of diabetics with erectile dysfunction

International Journal of Impotence Research
M A El-LatifS M Elhanbly

Abstract

Diabetes mellitus (DM) is the single most common cause of erectile dysfunction (ED) seen in clinical practice. Evaluation of penile arterial insufficiency in diabetic patients currently entails expensive and invasive testing. We assessed the diagnostic value of certain peripheral and cavernous blood markers as predictors of penile arterial insufficiency in diabetic men with ED. This study was conducted on a total of 51 subjects in three groups: 26 impotent diabetics, 15 psychogenic impotent men and 10 normal age matched control males. All subjects underwent standard ED evaluation including estimation of postprandial blood sugar and serum lipid profile. Peripheral venous levels of nitric oxide (NO), lipoprotein(a) (LP(a)), malondialdehyde (MDA) and glycosylated hemoglobin (HbA1c) were obtained in all subjects. Patients in the two impotent groups underwent additional measurement of NO, LP(a) and MDA levels in cavernous blood. They also underwent intracavernosal injection (ICI) of a trimix (papaverine, prostaglandin E1 and phentolamine mixture) and pharmaco-penile duplex ultrasonography (PPDU). Compared to patients in the psychogenic group, diabetic men had significantly lower erectile response to ICI (P<0.001), lower peak systoli...Continue Reading

References

Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Apr 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·A GriesG M Kostner
Dec 1, 1987·British Journal of Urology·L Q RobinsonT P Stephenson
Feb 19, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·M MatsumotoH Ibayashi
May 1, 1995·The American Journal of Medicine·A GriesmacherG Schernthaner
Sep 23, 1994·Cell·H H Schmidt, U Walter
Jun 2, 1998·International Urology and Nephrology·O AtahanA Metin
Jun 13, 2000·International Journal of Impotence Research·K E AnderssonP Alm
Jun 15, 2000·The New England Journal of Medicine·T F Lue
May 15, 2001·Biochemical and Biophysical Research Communications·T J BivalacquaH C Champion
Nov 6, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Ludovica PiconiAntonio Ceriello
Dec 24, 2004·Diabetes Care·Jeanette S BrownKevin T McVary
Jul 1, 2005·International Journal of Impotence Research·C ZippeR Raina
Aug 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Biljana MusickiArthur L Burnett
Nov 18, 2005·The Urologic Clinics of North America·Raymond C RosenNoel Gendrano

❮ Previous
Next ❯

Citations

Dec 17, 2009·Molecular & Cellular Proteomics : MCP·Elizabeth YohannesMark R Chance
May 27, 2009·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Kelvin P Davies, Arnold Melman
Oct 18, 2016·Journal of Ginseng Research·Ho Sung LeeJi Hoon Jeong
Feb 27, 2008·International Journal of Andrology·Farqad B Hamdan, Hisham Y Al-Matubsi
Jun 25, 2013·European Journal of Pharmacology·De-shan LiuJi-dong Zhang
Mar 14, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Zhengyuan ChenZhaoyun Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cavernous Hemangioma

Cavernous hemangioma is a blood vessel defect or benign tumor that leads to leakage of blood to the surrounding tissues. This can occur in several organs including the brain, which can lead to seizures. Discover the latest research on cavernous hemangiomas here.