PMID: 9643490Jun 27, 1998Paper

Diagnostic value of p53 immunohistochemistry in Barrett's esophagus: an endoscopic study

Pathology
S KhanJ R Jass

Abstract

The aim of this study was to establish the diagnostic utility of p53 immunohistochemistry in Barrett's esophagus. Three pathologists reviewed endoscopic biopsy specimens and one surgical specimen derived from 102 subjects in a prospective follow-up series. Dysplasia was graded as negative, indefinite, low grade and high grade. p53 staining was assessed as negative, weak or patchy and strong. Kappa coefficients for interobserver agreement for the three combinations of observer pairs were moderate to substantial (0.48, 0.55 and 0.68) for dysplasia and substantial to near perfect (0.77, 0.82 and 0.89) for p53 immunostaining. In the consensus grading achieved for dysplasia, strong p53 staining was recorded in 0/79 samples that were negative or indefinite for dysplasia, 5/15 (33%) examples of low grade dysplasia and 7/8 (87%) examples of high grade dysplasia. Non-dysplastic p53 positive glands were seen in specimens from two subjects harbouring dysplasia or cancer elsewhere. Two p53 positive specimens were, upon review and discussion, re-assigned from low- to high-grade dysplasia. It is concluded that p53 immunohistochemistry facilitates the interpretation of Barrett's epithelium but need only be employed to confirm a suspected diag...Continue Reading

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Citations

Oct 7, 2006·Current Opinion in Gastroenterology·S J Spechler
Aug 10, 2000·Histopathology·K Geboes, P Van Eyken
Jan 13, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S J WalkerN Birbeck
Jun 13, 2002·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J KleeffM W Büchler
Mar 19, 2014·Current Treatment Options in Gastroenterology·Shanmugarajah Rajendra, Prateek Sharma
Jun 14, 2002·Seminars in Oncology·Minetta C Liu, Edward P Gelmann
Dec 3, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shanmugarajah RajendraXiaojuan Wu
Dec 26, 2001·The American Journal of Medicine·S J Spechler
May 18, 2001·Best Practice & Research. Clinical Gastroenterology·J R Jass, I C Talbot
Oct 30, 2013·Gut·Rebecca C FitzgeraldUNKNOWN British Society of Gastroenterology
May 16, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Y S BianC Fontolliet
May 17, 2018·Digestive Diseases and Sciences·William M Grady, Ming Yu
Mar 1, 2000·Gastroenterology Clinics of North America·J C ReynoldsR R Yassin

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