Diagnostic value of plasma fibronectin level in predicting the presence and severity of coronary artery disease

Annals of Hematology
Fatih OzcelikMuzaffer Demir

Abstract

The relation between fibronectin and coronary artery disease (CAD) according to previous study results is controversial. The aim of the present study is to investigate the predictive value of fibronectin in determining the presence and severity of CAD. Patients with stable angina (n=62) who had angiographically documented CAD, and control patients (n=31) who had normal coronary angiograms, were included in the study. Plasma fibronectin levels were determined in all patients. Plasma fibronectin level (milligrams per liter) in patients with CAD was higher than normal controls (364.2+/-171 vs 265.1+/-135.5, p=0.006). The severity of CAD determined according to Gensini score and fibronectin level did not show any correlation (r=0.13, p=0.311). If fibronectin level 240 mg/l was determined as cutoff, it showed 76% sensitivity, 46% specificity, 46% negative predictive value, and 72.3% positive predictive value for predicting CAD. The present study showed that plasma fibronectin level in CAD is significantly higher than normal control subjects. However, it has no role in predicting the severity of CAD.

References

Jan 1, 1989·Cancer Investigation·M J HumphriesK M Yamada
Feb 1, 1983·The American Journal of Cardiology·G G Gensini
Nov 1, 1996·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M CucuianuD Colhon
Sep 1, 1997·Journal of the American College of Cardiology·M SchumacherW Klein
Sep 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·M K Magnusson, D F Mosher
Jan 14, 1999·The New England Journal of Medicine·R Ross
Nov 11, 1999·Circulation·E R FerreirósO O Bazzino
Feb 13, 2001·Atherosclerosis·K S SongS H Jee
Dec 12, 2001·Journal of the American College of Cardiology·A MazzoneC Falcone
Jan 29, 2005·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Hakan EkmekciEmine Kokoglu
Dec 27, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Ying ZhangFang Zheng

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Citations

Apr 20, 2012·EMBO Molecular Medicine·Ina RohwedderReinhard Fässler
Sep 20, 2011·Journal of Sleep Research·Bernabe Jurado-GamezDavid Gozal
Apr 20, 2010·Critical Care : the Official Journal of the Critical Care Forum·Oliver GrottkeRolf Rossaint
Nov 15, 2017·Nature Communications·Sophia DollMatthias Mann
Aug 28, 2020·Cardiology Research and Practice·Agnieszka Sapa-WojciechowskaIwona Bil-Lula

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