Diagnostic value of the late-night salivary cortisol in the diagnosis of clinical and subclinical Cushing's syndrome: results of a single-center 7-year experience

Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research
Nusret YilmazMustafa Kemal Balci

Abstract

Late-night salivary cortisol (LNSaC) is an easy-to-use test reflecting the free cortisol level in the serum and does not require hospitalization. Controlled studies reported that LNSaC has a high sensitivity and specificity, but have not set a clearly defined cut-off value to be used in the diagnosis of Cushing's syndrome. In this study, we aimed to evaluate the diagnostic performance of LNSaC in patients with clinical Cushing's syndrome (CCS) and subclinical Cushing's syndrome (SCS). The data of 543 patients, whose LNSaC levels were assessed using electrochemiluminescence immunoassay method, were retrospectively evaluated. The study included a total of 324 patients: 58 patients with CCS, 53 patients with SCS, and 213 patients without Cushing's syndrome (NoCS). The cause of the Cushing's syndrome was hypophyseal in 26 patients (45%), adrenal in 24 patients (41%), and ectopic in 8 patients (14%) in the CCS group. Median LNSaC levels were 0.724 (0.107-33) µg/dL in CCS group, 0.398 (0.16-1.02) µg/dL in SCS group, and 0.18 (0.043-0.481) µg/dL in NoCS group (p=0.001). Accordingly, LNSaC had 89.6% sensitivity and 81.6% specificity at a cut-off value of 0.288 µg/dL in the diagnosis of CCS; and had 80.7% sensitivity and 85.1% specifici...Continue Reading

References

Jul 1, 1984·The Journal of Clinical Endocrinology and Metabolism·A R GlassM Schaaf
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Maria YanevaXavier Bertagna
Mar 13, 2008·The Journal of Clinical Endocrinology and Metabolism·Lynnette K NiemanVictor M Montori
Aug 30, 2008·The Journal of Clinical Endocrinology and Metabolism·Carmen A CarrascoJérôme Bertherat
Nov 13, 2008·The Journal of Clinical Endocrinology and Metabolism·Marie-Laure NunesAntoine Tabarin
Jun 9, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ty CarrollJames W Findling
Jul 28, 2009·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Martha A ZeigerUNKNOWN American Association of Endocrine Surgeons
Dec 9, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gabriella BekoAttila Patocs
Jul 16, 2010·The Journal of Clinical Endocrinology and Metabolism·R Kurdi ZeriklyA H Hamrahian
Jul 17, 2010·Postgraduate Medical Journal·K JeyaramanS N Dwivedi
Aug 26, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Antonio León-JustelAlfonso Leal-Cerro
Aug 19, 2015·European Journal of Endocrinology·Guido Di DalmaziMartin Reincke

❮ Previous
Next ❯

Citations

Mar 7, 2020·The Journal of Clinical Endocrinology and Metabolism·Brandon P GalmNicholas A Tritos
Mar 25, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Stephan Petersenn
Apr 6, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Carmen ArestaIacopo Chiodini
Jan 21, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Nusret YilmazMustafa Kemal Balci

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.