Diagnostic value of urinary enzyme determination in renal transplantation

Transplant International : Official Journal of the European Society for Organ Transplantation
E SárváryF Perner

Abstract

The measurement of enzyme activity in urine provides a sensitive assessment for renal tubular cell damage. The present study was undertaken to evaluate the clinical value of the determination of tubular brush-border-associated enzymes, alkaline phosphatase (AP), gamma-glutamyl transferase (GGT), leucine aminopeptidase (LAP), and dipeptidyl peptidase IV (DPP), of patients with normal graft function (NOR, n = 20), with acute tubular necrosis (ATN, n = 11), with an acute rejection episode (ARE, n = 17) after transplantation, and of healthy persons (n = 20). The second urine of the morning was collected daily during the patients' stay in hospital. The enzyme activities were measured at 25 degrees C and were expressed as U/mmol creatinine. The enzymuria in NOR is higher than in healthy controls, but is still in the normal range. By 5 days after transplantation the initial increased excretion declines as the graft function improves. Elevated enzymuria (DPP 0.69 +/- 0.56, AP 3.06 +/- 3.24, GGT 4.16 +/- 4.13, and LAP 1.39 +/- 1.27) was observed during the rejection episodes. Two days before clinical diagnosis of rejection, the release of DPP-IV and GGT increases to double, and the AP and LAP increases to 3 times the value on the fourth...Continue Reading

References

Jan 1, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·R F DyckM A Sacks
Jan 1, 1970·Clinica Chimica Acta; International Journal of Clinical Chemistry·N DanceB Richards
Jun 15, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·P H WhitingN Edward
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Nov 20, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·P H WhitingJ Engeset

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Citations

Nov 5, 2011·Nephrology·Yi-Tian TingAlexander D McLellan
Feb 28, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Birgit HoldtMichael Steiner
Jun 21, 2008·Advances in Chronic Kidney Disease·Charles L Edelstein
Mar 18, 2008·Orvosi hetilap·Eniko SárváryJeno Járay
Mar 24, 2017·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Andriy V TrailinOlexander S Nikonenko

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