Abstract
Women who have been treated for breast cancer are typically followed up with regular mammography and palpation, with the aim of detecting recurrences and contralateral breast cancer (CBC). This study aims to investigate if the diagnostic work-up of breast cancer patients has improved over the last 25 years and resulted in earlier diagnoses of CBC. Two population-based cohorts were used; all CBCs in Sweden 1976-2004 (n: 2932), and all CBCs in Stockholm, Sweden, 1976-2005 (n: 626), both cohorts with a maximum of 3 years between the two cancers. Synchronous CBC was defined as two cancers <3 months apart, the remainder was defined as metachronous CBC. We calculated the odds ratio of being diagnosed synchronously, relative to metachronously, using logistic regression, adjusting for whether the second cancer was detected through clinical work-up or not. The odds of synchronous CBC were significantly increased: 1.27 (95% CI, 1.13-1.42) per 5-year period, compared to metachronous, and was not affected by detection mode, but seemed to be explained by adjuvant therapy. The proportion of CBCs detected by clinical work-up did not increase over the study period, and the mean size of the second tumor remained constant. We found an increase i...Continue Reading
References
Feb 1, 1985·Cancer·H O AdamiJ Hansen
Jan 1, 1984·Acta Radiologica. Oncology·B Mattsson, A Wallgren
Aug 1, 1995·Radiology·M A RoubidouxC Paramagul
Mar 1, 1996·Maturitas·S M McKinlay
Apr 1, 1997·Annals of Surgical Oncology·T J YeatmanC E Cox
May 12, 2000·Journal of Medical Screening·S OlssonS Håkansson
Aug 16, 2000·Radiologic Clinics of North America·R E Hendrick, E A Berns
Oct 3, 2000·Surgery·E S HungnessP O Hasselgren
Aug 24, 2001·Breast Cancer Research and Treatment·Y ChenY Mao
Feb 15, 2002·The Breast Journal·R S SamantD Mates
Jun 7, 2002·Ultrasound in Medicine & Biology·Ming-Feng HouTsung-Jen Huang
Oct 2, 2002·Radiology·Thomas M KolbJeffrey H Newhouse
Nov 7, 2002·Journal of the National Cancer Institute·Angela MariottoJeffrey Abrams
Apr 30, 2003·Surgery·Anthony P Polednak
Dec 1, 1964·Cancer·G F ROBBINS, J W BERG
Dec 9, 2003·The Breast : Official Journal of the European Society of Mastology·J J JobsenJ H Meerwaldt
Jun 24, 2004·British Journal of Cancer·M M VervoortH J de Koning
May 17, 2005·Lancet·UNKNOWN Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
Jun 16, 2005·International Journal of Cancer. Journal International Du Cancer·Håkan JonssonPer Lenner
Feb 18, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Linda C HarlanRachel Ballard-Barbash
Nov 18, 2006·Cancer Causes & Control : CCC·Linda Titus-ErnstoffPatricia A Carney
Mar 30, 2007·The New England Journal of Medicine·Constance D LehmanUNKNOWN ACRIN Trial 6667 Investigators Group
May 2, 2007·Cancer·UNKNOWN Swedish Organised Service Screening Evaluation Group
Aug 10, 2007·Breast Cancer Research and Treatment·Michael SchaapveldFlora E van Leeuwen
Sep 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mikael HartmanPer Hall
Oct 9, 2007·Clinical Breast Cancer·Andrew RobinsonStephen Chia
Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael SchaapveldFlora E van Leeuwen
Aug 30, 2008·Acta Oncologica·Levent KemetliSven Törnberg
Sep 4, 2008·Acta Oncologica·Lotti BarlowMats Talbäck
Jan 22, 2009·AJR. American Journal of Roentgenology·Wendie A Berg