Diagnostic workup for fever of unknown origin: a multicenter collaborative retrospective study

BMJ Open
Toshio NaitoJun Hayashi

Abstract

Fever of unknown origin (FUO) can be caused by many diseases, and varies depending on region and time period. Research on FUO in Japan has been limited to single medical institution or region, and no nationwide study has been conducted. We identified diseases that should be considered and useful diagnostic testing in patients with FUO. A nationwide retrospective study. 17 hospitals affiliated with the Japanese Society of Hospital General Medicine. This study included patients ≥18 years diagnosed with 'classical fever of unknown origin' (axillary temperature ≥38°C at least twice over a ≥3-week period without elucidation of a cause at three outpatient visits or during 3 days of hospitalisation) between January and December 2011. A total of 121 patients with FUO were enrolled. The median age was 59 years (range 19-94 years). Causative diseases were infectious disease in 28 patients (23.1%), non-infectious inflammatory disease in 37 (30.6%), malignancy in 13 (10.7%), other in 15 (12.4%) and unknown in 28 (23.1%). The median interval from fever onset to evaluation at each hospital was 28 days. The longest time required for diagnosis involved a case of familial Mediterranean fever. Tests performed included blood cultures in 86.8%, se...Continue Reading

Citations

Mar 4, 2015·Open Forum Infectious Diseases·Sarah S LewisJason E Stout
Jan 9, 2016·Japanese Journal of Infectious Diseases·Cui-Ping LiuJia Shang
Aug 19, 2015·Internal Medicine·Takaaki Ishiyama, Toshinori Takada
Jun 13, 2014·European Journal of Clinical Investigation·Pilar Brito-ZerónXavier Bosch
Jun 3, 2015·Clinical Medicine : Journal of the Royal College of Physicians of London·Catharina Mulders-MandersChantal Bleeker-Rovers
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Jul 25, 2019·BMC Infectious Diseases·Francesco Maria FuscoGiuseppina Brancaccio
Jan 18, 2017·Wiener klinische Wochenschrift·Jin ShangHong Tang
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Mar 14, 2019·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Mile BosilkovskiIvan Vidinic

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Methods Mentioned

BETA
biopsy
biopsies
ESR

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