Diagnostic Yield and Safety of Cerebellar and Brainstem Parenchymal Biopsy

World Neurosurgery
W Oliver TobinB Mark Keegan

Abstract

We aimed to determine the diagnostic yield and safety of posterior fossa parenchymal biopsy. One-hundred-thirty-six patients who underwent 137 posterior fossa (brainstem or cerebellar) parenchymal biopsies at Mayo Clinic (Rochester, Minnesota, USA) between 1996 and 2009 were identified by chart review. Case histories; radiologic, surgical, and pathologic reports; and safety outcomes were assessed. Posterior fossa parenchymal biopsies were performed on 78 male and 58 female patients of median age 47 years (interquartile range 28-61). Preoperative clinical diagnosis in the majority of cases was of a malignant neoplasm. Glial neoplasm (51%) was the most common finding followed by lymphoma (7%) and neurosarcoidosis (7%). Normal tissue or nonspecific changes were observed in 28 cases (20%). Three deaths occurred: 2 at the time of biopsy (1%) and 1 due to underlying disease. All deaths occurred in patients who had a cerebellar biopsy. Transient neurologic deficits occurred in 15 patients (11%): worsening of presenting symptoms (4), cardiac arrhythmia (3), vertigo (2), diplopia (2), ataxia (3), seizure (1), decreased consciousness (1), and limb numbness (3). Sustained neurologic deficits occurred in 3 patients: fourth nerve palsy (1),...Continue Reading

References

Jan 27, 2004·Stereotactic and Functional Neurosurgery·Uzma Samadani, Kevin D Judy
Jan 24, 2006·Surgical Neurology·Marcelo Paglioli FerreiraAndré Cerutti Franciscatto
Jun 13, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·W RachingerF W Kreth
Sep 24, 2010·Stereotactic and Functional Neurosurgery·Vedantam Rajshekhar, Ranjith K Moorthy

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Citations

Nov 22, 2017·Brain : a Journal of Neurology·W Oliver TobinB Mark Keegan
Jul 21, 2017·Current Neurology and Neuroscience Reports·Nicholas L Zalewski, W Oliver Tobin
Mar 3, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Elena AnghileriValeria Cuccarini
Jul 14, 2020·European Journal of Internal Medicine·Bertrand MathonUNKNOWN PSL BRAIN-BIOPSY STUDY GROUP
Jul 29, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Feng QinZhengqi Lu

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