PMID: 25773847Mar 17, 2015Paper

Diagnostic yield of primary circulating tumor cells in women suspected of breast cancer: the BEST (Breast Early Screening Test) study

Asian Pacific Journal of Cancer Prevention : APJCP
Nigel P MurrayElsa Droguett

Abstract

To determine the diagnostic yield of primary circulating tumor cells in women with suspicion of breast cancer, detected as a result of an abnormal mammography. Consecutive women presenting for breast biopsy as a result of a mammogram BiRADs of 3 or more, had an 8 ml blood sample taken for primary circulating tumor cell (CTC) detection. Mononuclear cells were obtained using differential gel centrifugation and CTCs identified using standard immunocytochemistry using anti-mammoglobin. A test was determined to be positive if 1 CTC was detected. A total of 144 women with a mean age of 54.7 ± 15.6 years participated, 78/144 (53.0%) had breast cancer on biopsy, 65/140 (46.3%) benign pathologies and 1(0.7%) non-Hogkins lymphoma. Increasing BiRADs scores were associated with increased cancer detection (p=0.004, RR 1.00, 4.24, 8.50). CTC mammoglobin positive had a sensitivity of 81.1% and specificity of 90.9%, with positive and negative predictive values of 90.9% and 81.1% respectively. Mammoglobin positive CTCs detected 87% of invasive cancers, while poorly differentiated cancers were negative for mammoglobin. Only 50% of in situ cancers and none of the intraductal cancers had CTCs detected. Menopausal status did not affect the diagnost...Continue Reading

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Citations

Dec 8, 2016·Biomarkers in Medicine·William L HwangDavid T Miyamoto
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wei ZhangLiu Yang
Feb 5, 2019·Rejuvenation Research·Fengfeng CaiEwelina Biskup
Jan 13, 2018·Advanced Drug Delivery Reviews·William L HwangDavid T Miyamoto

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