Diagnostics for herpes simplex virus: is PCR the new gold standard?

Molecular Diagnosis & Therapy
Lara B Strick, Anna Wald

Abstract

Herpes simplex virus (HSV) is one of the most common, yet frequently overlooked, sexually transmitted infections. Since the type of HSV infection affects prognosis and subsequent counseling, type-specific testing to distinguish HSV-1 from HSV-2 is recommended. Although PCR has been the diagnostic standard for HSV infections of the central nervous system, until now viral culture has been the test of choice for HSV genital infection. However, HSV PCR, with its consistently and substantially higher rate of HSV detection, will likely replace viral culture as the gold standard for the diagnosis of genital herpes in people with active mucocutaneous lesions, regardless of anatomic location or viral type. Alternatively, type-specific serologic tests based on glycoprotein G should be the test of choice to establish the diagnosis of HSV infection when no active lesion is present. Given the difficulty in making the clinical diagnosis of HSV, the growing worldwide prevalence of genital herpes and the availability of effective antiviral therapy, there is an increased demand for rapid, accurate laboratory diagnosis of patients with HSV.

References

Jun 4, 1992·The New England Journal of Medicine·L A KoutskyL Corey
Apr 1, 1992·Bio/technology·R HiguchiR Griffith
Dec 1, 1992·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C G ProberA M Arvin
May 1, 1991·American Journal of Obstetrics and Gynecology·P M CatalanoP B Mead
Jul 26, 1990·The New England Journal of Medicine·R J Whitley
Nov 21, 1985·The New England Journal of Medicine·S Stagno, R J Whitley
Jul 15, 1971·American Journal of Obstetrics and Gynecology·A J NahmiasJ H Wheeler
Jun 1, 1982·The Journal of Infectious Diseases·A J NahmiasC A Alford
Dec 1, 1995·Annals of Internal Medicine·M AugenbraunH Minkoff
Jan 1, 1996·Annals of Internal Medicine·A WaldL Corey
Sep 21, 1995·The New England Journal of Medicine·A WaldL Corey
Feb 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R J Whitley, F Lakeman
Dec 1, 1994·Annals of Internal Medicine·J BenedettiR Ashley
Sep 14, 1994·JAMA : the Journal of the American Medical Association·R W ConeL Corey
Jul 7, 1993·JAMA : the Journal of the American Medical Association·A G RandolphC G Prober
Jan 1, 1996·Obstetrics and Gynecology·L L ScottG D Wendel
Jan 1, 1997·BioTechniques·C T WittwerR P Rasmussen

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Citations

Jun 3, 2014·Virology Journal·Jérôme LeGoffLaurent Bélec
Feb 4, 2010·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Robert Yetman
Oct 16, 2015·Virology Journal·Jérôme LeGoffLaurent Bélec
Mar 31, 2016·Future Microbiology·Gilbert GreubKatia Jaton
Nov 23, 2011·Diagnostic Microbiology and Infectious Disease·Ju-Hsien J C NienaberMuhammad R Sohail
Jun 29, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lara B StrickConnie Celum
Jul 2, 2014·Clinical Microbiology Reviews·Marios ArvanitisEleftherios Mylonakis
Jan 17, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Paolo G Arduino, Stephen R Porter
Oct 5, 2010·International Journal of Dermatology·Nicholas NguyenCraig G Burkhart
Feb 9, 2012·Current Infectious Disease Reports·Nicholas J Van Wagoner, Edward W Hook
Jul 19, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Mariola KuczerDanuta Konopińska
Nov 5, 2014·Internal Medicine·Margaret CasesDick E Zoutman
Apr 9, 2020·Pediatric Emergency Care·Sriram RamgopalTodd A Florin
Nov 21, 2020·Viruses·Jacek BajGrzegorz Teresiński
Jul 3, 2021·Infectious Disease Reports·Peuli NathAniruddha Ray
Sep 16, 2021·Journal of Investigative Medicine High Impact Case Reports·Parker BrownMansi Sarihan
Jan 23, 2010·The Journal of Sexual Medicine·Hossein Sadeghi-NejadDavid Goldmeier
Aug 14, 2010·Primary Care·John R Brill
Aug 30, 2011·The Journal of Molecular Diagnostics : JMD·Rajyasree EmmadiKathryn Bernard

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