Diagnostics for onchocerciasis in the era of elimination

International Health
Thomas R UnnaschPaul T Cantey

Abstract

In the past few years, efforts to eliminate onchocerciasis from Africa have intensified. These efforts are primarily based on the mass distribution of the anti-helminthic drug Mectizan™ (ivermectin). This program has led to the development of new guidelines by the World Health Organization for the verification that transmission has been suppressed and eventually eliminated. The requirements of diagnostic tools for this purpose differ in many ways from tests used to diagnose infection in individuals. In this review, we summarize the progress that has been made to identify diagnostics that meet the specialized requirements needed to verify onchocerciasis elimination, discuss why these tests were selected and summarize the needs that still exist to complete the arsenal of diagnostic tools that will be useful as the goal of elimination is achieved.

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Citations

Feb 23, 2018·International Health·Paul T CanteyYao K Sodahlon
Jun 16, 2019·The Journal of Infectious Diseases·Sasisekhar BennuruThomas B Nutman
Jun 11, 2020·Diagnostics·Emma Michelle Taylor
Aug 29, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Manon GeertsPhilippe Büscher
Sep 20, 2019·Microorganisms·Shunbin Xu, Linda D Hazlett
Mar 25, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Housseini DoloMaria-Gloria Basáñez
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Jul 29, 2021·PLoS Neglected Tropical Diseases·Elizabeth A CromwellDavid M Pigott
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