PMID: 32156837Mar 12, 2020Paper

Diagostic Accuracy of C4d-IHC in Diagnosis of MGN.

Iranian Journal of Kidney Diseases
Peyman Mohammadi Torbati, Haleh Tavakolian

Abstract

Membranous glomerulonephritis (MGN) is the most common cause of nephrotic syndrome in adults. The gold standard techniques for diagnosis of MGN are based on a constellation of findings given by light microscope, electron microscope (EM), and immunofluorescence (IF). Occasionally, only formalin-fixed tissues are available for the analysis by light microscopy, which have limitations in differentiating minimal change diseases from MGN. Recently, the usage of C4d immunohistochemistry (IHC) has been proposed for the diagnosis of MGN. The aim of this study was to evaluate the accuracy of C4d-IHC in diagnosis of MGN. The present investigation conducted on patients with nephrotic syndrome who underwent renal biopsy in Labbafinejad hospital, from 2016 to 2017. The entire specimens were examined by light microscope, immunofluorescence, and electron microscope as a gold standard method for diagnosis of MGN. The samples were then stained for C4d immunohistochemical analysis. Eventually, the sensitivity, specificity, positive, and negative predictive value for C4d-IHC was determined. The sensitivity and specificity of the C4d-IHC in order to differentiate MGN from other glomerulopathies were 95% and 87.5%, respectively. In addition, the neg...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Nephrology
W H Hörl, D Kerjaschki
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
G MongaA Amoroso
Zentralblatt für allgemeine Pathologie und pathologische Anatomie
G Ditscherlein, W Schneider
© 2021 Meta ULC. All rights reserved