Diallyl Disulfide Prevents Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats through the Inhibition of Oxidative Damage, MAPKs, and NF-κB Pathways

Biomolecules & Therapeutics
Sung-Hwan KimJong-Choon Kim

Abstract

This study investigated the possible effects and molecular mechanisms of diallyl disulfide (DADS) against cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) in rats. Inflammation response was assessed by histopathology and serum cytokines levels. We determined the protein expressions of nuclear transcription factor kappa-B (NF-κB), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and tumor necrosis factor-α (TNF-α), oxidative stress, urinary nitrite-nitrate, malondialdehyde (MDA), and 8-hydroxy-2'-deoxyguanosine (8-OHdG). Finally, we studied the involvement of mitogen-activated protein kinases (MAPKs) signaling in the protective effects of DADS against CP-induced HC. CP treatment caused a HC which was evidenced by an increase in histopathological changes, proinflammatory cytokines levels, urinary nitrite-nitrate level, and the protein expression of NF-κB, COX-2, iNOS, TNF-α, p-c-Jun N-terminal kinase (JNK), and p-extracellular signal regulated kinase (ERK). The significant decreases in glutathione content and glutathione-S-transferase and glutathione reductase activities, and the significant increase in MDA content and urinary MDA and 8-OHdG levels indicated that CP-induced bladder injury was mediated thro...Continue Reading

References

Aug 8, 1997·The Journal of Biological Chemistry·K B Beckman, B N Ames
Dec 2, 1998·Molecular Carcinogenesis·T R BertonS M Fischer
Jul 25, 2003·European Journal of Pharmacology·José Pedraza-ChaverríRogelio Hernández-Pando
Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T FukaoT Ariga
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Riku KorhonenEeva Moilanen
Jul 11, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K BhatiaS Raisuddin
Mar 16, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yasuhiro HamadaMasato Kasuga
Apr 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kimberly A Corrow, Margaret A Vizzard
Aug 30, 2007·Cellular and Molecular Life Sciences : CMLS·Y Zhang, C Dong
Sep 18, 2008·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·José Miguel JuradoEmilio Alba
Apr 21, 2009·International Immunopharmacology·Rahul CheckerT B Poduval
Feb 4, 2010·Acta Cirúrgica Brasileira·Anna Carolina Batista DantasAldo Cunha Medeiros
Sep 8, 2010·Experimental Gerontology·Sara CuestaJesús A F Tresguerres
Oct 12, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T P Hamsa, Girija Kuttan
May 10, 2011·Free Radical Biology & Medicine·Antonio Martínez-RuizSantiago Lamas
Jan 31, 2012·Cellular Signalling·Paul D RayYoshiaki Tsuji
Nov 20, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·In-Chul LeeJong-Choon Kim
Dec 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sung-Hwan KimHyoung-Chin Kim

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Citations

Apr 19, 2016·Current Pharmacology Reports·Am Sashi Papu JohnChendil Damodaran
Feb 26, 2016·The International Journal of Biochemistry & Cell Biology·Iman O SherifOsama M Sarhan
Feb 22, 2017·Scientific Reports·Muhammad Jahangir HossenJae Youl Cho
Apr 12, 2018·Journal of Cardiovascular Pharmacology·Hai-Bing YangZhao-Yang Lu
Dec 24, 2019·American Journal of Physiology. Renal Physiology·Nathan A HirshmanJ Todd Purves
Jun 27, 2021·The Journal of Pharmacy and Pharmacology·Tarek Mohamed Kamal MotawiHanan Muhammad Abd-Elgawad
Jun 3, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Amal A El-KholyDina S El-Agamy
Aug 15, 2021·Journal of Biochemical and Molecular Toxicology·Emad H M HassaneinAyman M Mahmoud
Nov 4, 2020·Journal of Agricultural and Food Chemistry·Jinxin XieRi-Yuan Tang

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Methods Mentioned

BETA
MDA
enzyme-linked immunosorbent assay
ELISA
Protein Assay

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