Diallyl trisulfide increases the effectiveness of TRAIL and inhibits prostate cancer growth in an orthotopic model: molecular mechanisms

Molecular Cancer Therapeutics
Sharmila ShankarRakesh K Srivastava

Abstract

Recent studies have shown that naturally occurring compounds can enhance the efficacy of chemotherapeutic drugs. The objectives of this study were to investigate the molecular mechanisms by which diallyl trisulfide (DATS) enhanced the therapeutic potential of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in prostate cancer cells in vitro and on orthotopically transplanted PC-3 prostate carcinoma in nude mice. DATS inhibited cell viability and colony formation and induced apoptosis in PC-3 and LNCaP cells. DATS enhanced the apoptosis-inducing potential of TRAIL in PC-3 cells and sensitized TRAIL-resistant LNCaP cells. Dominant-negative FADD inhibited the synergistic interaction between DATS and TRAIL on apoptosis. DATS induced the expression of DR4, DR5, Bax, Bak, Bim, Noxa, and PUMA and inhibited expression of Mcl-1, Bcl-2, Bcl-X(L), survivin, XIAP, cIAP1, and cIAP2. Oral administration of DATS significantly inhibited growth of orthotopically implanted prostate carcinoma in BALB/c nude mice compared with the control group, without causing weight loss. Cotreatment of mice with DATS and TRAIL was more effective in inhibiting prostate tumor growth and inducing DR4 and DR5 expression, caspase-8 activity, and apopt...Continue Reading

References

Jan 1, 1994·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Z H FengZ Y Jiang
Nov 15, 1996·Genes & Development·K WangS J Korsmeyer
Aug 28, 1998·Science·D R Green, J C Reed
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·R K SrivastavaD L Longo
May 10, 2000·Nature Medicine·G Kroemer, J C Reed
Feb 15, 2001·Molecular Cell Biology Research Communications : MCBRC·R K Srivastava
Jan 5, 2002·Neoplasia : an International Journal for Oncology Research·R K Srivastava
Aug 13, 2003·Journal of Thrombosis and Haemostasis : JTH·J Folkman
May 26, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Sharmila Shankar, Rakesh K Srivastava
Oct 6, 2004·Expert Opinion on Investigational Drugs·Bharat B AggarwalOommen V Oommen
Feb 3, 2005·World Journal of Urology·Daniel P Petrylak
May 18, 2005·Oncogene·Thiyam Ramsing SinghRakesh K Srivastava
May 5, 2006·Molecular Carcinogenesis·Michael Karin
Aug 8, 2006·Biochemical Pharmacology·Bharat B AggarwalGautam Sethi
Oct 30, 2007·Biochimica Et Biophysica Acta·Bing-Hua Jiang, Ling-Zhi Liu
Nov 3, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Robert Q MiaoWilliam C Sessa
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Sharmila ShankarRakesh K Srivastava
Nov 13, 2007·Biochimica Et Biophysica Acta·Romina MaroneMatthias P Wymann
Nov 30, 2007·Cancer Metastasis Reviews·Adriana AlbiniUlrich Pfeffer
Feb 19, 2008·The International Journal of Biochemistry & Cell Biology·Lewis J StaffordDanny R Welch
Feb 22, 2008·Current Cancer Drug Targets·Eriko TokunagaYoshihiko Maehara

❮ Previous
Next ❯

Citations

Jun 6, 2009·Antioxidants & Redox Signaling·Georg T Wondrak
Dec 18, 2013·Pharmacology & Therapeutics·Hyung-Mun YunJin Tae Hong
Aug 25, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Qing XiaHao Li
Nov 6, 2010·Journal of Cellular Biochemistry·Byeong-Chel LeeYong J Lee
Sep 11, 2014·Pigment Cell & Melanoma Research·Elisabetta PanzaAngela Ianaro
Mar 29, 2016·Prostate Cancer·Mingzhe LiuGuangdong Yang
Aug 19, 2014·Bioscience, Biotechnology, and Biochemistry·Shun SudaTaiichiro Seki
Jan 17, 2020·International Journal of Molecular Sciences·Chinatsu NakagawaYoshihiro Suzuki-Karasaki
Aug 10, 2017·International Journal of Molecular Sciences·Michael T Puccinelli, Silvia D Stan
Apr 10, 2019·Anti-cancer Agents in Medicinal Chemistry·Saleh A AlmatroodiArshad H Rahmani
Dec 5, 2020·Molecular Nutrition & Food Research·Jessica K HitchcockCatherine H Kaschula
Dec 11, 2020·Seminars in Cancer Biology·Danielle De GreefAnupam Bishayee
May 29, 2021·Nutrition and Health·Angela Lincy Prem Antony SamyGnanasekar Munirathinam
Jun 2, 2021·Critical Reviews in Food Science and Nutrition·Xiaoming LuLi Ningyang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis