Dialog between skin and its microbiota: Emergence of "Cutaneous Bacterial Endocrinology".

Experimental Dermatology
Pierre-Jean RacineMarc G J Feuilloley

Abstract

Microbial endocrinology is studying the response of microorganisms to hormones and neurohormones and the microbiota production of hormones-like molecules. Until now, it was mainly applied to the gut and revealed that the intestinal microbiota should be considered as a real organ in constant and bilateral interactions with the whole human body. The skin harbours the second most abundant microbiome and contains an abundance of nerve terminals and capillaries, which in addition to keratinocytes, fibroblasts, melanocytes, dendritic cells and endothelial cells, release a huge diversity of hormones and neurohormones. In the present review, we will examine recent experimental data showing that, in skin, molecules such as substance P, calcitonin gene-related peptide, natriuretic peptides and catecholamines can directly affect the physiology and virulence of common skin-associated bacteria. Conversely, bacteria are able to synthesize and release compounds including histamine, glutamate and γ-aminobutyric acid or peptides showing partial homology with neurohormones such as α-melanocyte-stimulating hormone (αMSH). The more surprising is that some viruses can also encode neurohormones mimicking proteins. Taken together, these elements demo...Continue Reading

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Citations

Feb 7, 2021·International Journal of Molecular Sciences·Lucas André Cavalcanti BrandãoSergio Crovella
Mar 16, 2021·Molecular and Cellular Endocrinology·R M SlominskiR C Tuckey
Dec 16, 2020·Experimental Dermatology·Markus Böhm, Ralf Paus
Apr 1, 2021·Scientific Reports·Maximilien ClabautMarc G J Feuilloley
Apr 4, 2021·Microorganisms·Maria Alekseevna OvcharovaAndrei Vladislavovich Gannesen
Apr 24, 2021·Scientific Reports·Daniela PintoFabio Rinaldi
Jun 3, 2021·Scientific Reports·Maximilien ClabautMarc G J Feuilloley

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