PMID: 7336974Sep 1, 1981Paper

Dialysability of benzodiazepines by haemodialysis and controlled sequential ultrafiltration (CSU) in vitro

Acta Pharmacologica Et Toxicologica
A BaloghA Pekkarinen

Abstract

The efficacy of haemodialysis and controlled sequential ultrafiltration (CSU) for the elimination of three hypnotic and 6 benzodiazepine drugs was compared in vitro. In comparison to haemodialysis the efficacy of ultrafiltration by CSU was poor, as the mean per cent of CSU/haemodialysis (mg/hr) for 5 benzodiazepines was only 0.6-4.0% and for three hypnotics, phenobarbital 3.4%, pyrithyldione 8.2% and glutethimide 2.5% of the haemodialysis values. In haemodialysis in vitro phenobarbital, pyrithyldione, glutethimide and chlordiazepoxide were significantly and markedly more dialysable than 5 other benzodiazepines. The mean clearance of six benzodiazepine derivatives was about 2 to 3 times higher at blood flow rates of 200 ml/min. than 100 ml/min. In CSU experiments in vitro it was possible to remove approximately (as the mean percent of the initial dose) only the amount of five benzodiazepines corresponding to the per cent of the protein unbound fraction in the plasma (correlation r = 0.975, P less than 0.01). Only low amounts of three hypnotics, especially glutethimide, were removed by CSU in vitro.

References

Jan 30, 1976·Deutsche medizinische Wochenschrift·B GrabenseeE Schnurr
Nov 1, 1977·Clinical Pharmacokinetics·T B Gibson, H A Nelson
Dec 9, 1977·Deutsche medizinische Wochenschrift·H BlankeF Scheler
Dec 16, 1977·European Journal of Clinical Pharmacology·L KangasR Erkkola
Jan 1, 1978·Nephron·K F Kopp
Dec 1, 1977·Clinical Pharmacology and Therapeutics·D J GreenblattJ Koch-Weser
Dec 1, 1976·Clinical Pharmacology and Therapeutics·T P GibsonW A Briggs
Jan 4, 1975·British Medical Journal·J A ValeR Goulding
Jan 30, 1976·Deutsche medizinische Wochenschrift·H HennemannA Heidland
Jan 1, 1972·Transactions - American Society for Artificial Internal Organs·J D AndradeW J Kolff
Sep 1, 1971·Clinical Pharmacology and Therapeutics·S H CurryC McMartin
Mar 1, 1958·Clinica Chimica Acta; International Journal of Clinical Chemistry·R RICHTERICH

❮ Previous
Next ❯

Citations

Mar 1, 1989·Biopharmaceutics & Drug Disposition·S S YuP R Gwilt
Jan 1, 1991·European Journal of Clinical Pharmacology·J SennesaelS R Bareggi
Apr 11, 2015·Seminars in Dialysis·Rachel F EylerAloun Mary Vilay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.