PMID: 8591122Oct 1, 1995Paper

Dialysate-based kinetic modeling

Advances in Renal Replacement Therapy
L J Garred

Abstract

The focus of this review article is urea kinetic modeling based on the exploitation of concentration measurements in the spent dialysate stream. After a review of blood-based urea kinetic modeling, dialysate-based techniques are considered, beginning with dialysate collection techniques and their associated urea kinetic modeling equations. Partial dialysate collection methods and equations for the determination of protein catabolic rate based on a 7-day mass balance period are explored next. This is followed by a description of urea sensors and their application for dialysate-based modeling including the determination of protein catabolic rate, predialysis blood urea nitrogen (BUN), and KT/V. How the output of a urea sensor may allow the detection of significant changes in patient clearance during the course of dialysis is illustrated, as well as how double-pool urea kinetics may be accounted for in KT/V determination. Routine determination of patient lean body mass using creatinine kinetic modeling based on partial dialysate collection or a dialysate-based creatinine concentration sensor is demonstrated. Finally, the potential for complete automation of urea kinetic modeling in dialysis machines of the future is explored.

Citations

Jul 7, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Enrico FiaccadoriAderville Cabassi
Apr 10, 2007·The International Journal of Artificial Organs·R RatanaratC Ronco
Feb 15, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nigel S KanagasundaramUNKNOWN Project for the Improvement of the Care of Acute Renal Dysfunction Study Group
Sep 26, 2002·The International Journal of Artificial Organs·I FridolinL G Lindberg
Aug 2, 2003·Medical & Biological Engineering & Computing·E A FernándezC A Perazzo
Aug 11, 2000·Kidney International. Supplement·A Santoro
Oct 17, 2002·Advances in Renal Replacement Therapy·Emil P PaganiniDavid Wensley
Nov 25, 2003·Kidney International·Nigel S KanagasundaramUNKNOWN Project for the Improvement of the Care of Acute Renal Dysfunction (PICARD) Study Group
Mar 6, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mark R MarshallDinesh K Chatoth

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