Dialysis and iodinated contrast media

Kidney International. Supplement
G Deray

Abstract

Contrast media are excreted mainly by glomerular filtration. There is thus, a significant correlation between both body and renal clearances of contrast media and glomerular filtration rate, and their renal excretion will be delayed in patients with renal insufficiency. Contrast media can be efficiently removed from blood by hemodialysis (HD). Since most contrast media are middle-sized molecules, the main factors potentially influencing their removal by HD are blood flow, membrane surface area, molecular size, transmembrane pressure, and dialysis time. Peritoneal dialysis is also effective in removing contrast agents from the body but takes longer than HD. Dialysis immediately after radiographic contrast studies has been suggested for two groups of patients. Those on chronic HD and those at very high risk for contrast nephropathy. Three studies have examined the necessity of immediate dialysis after intravascular injection of contrast media in chronic HD patients; the authors found no evidence that it is effective at preventing contrast nephropathy. The reasons why HD treatment was not beneficial in those three studies are not known. Perhaps, the rapid onset of renal injury after administration of contrast media is one answer. ...Continue Reading

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