Dialysis-assisted fiber optic spectroscopy for in situ biomedical sensing

Journal of Biomedical Optics
P BlazkiewiczA V Zvyagin

Abstract

A miniature fiber optic spectrometer enclosed within a semipermeable (dialysis) membrane is proposed for in vivo interstitial sensing applications. The semipermeable membrane acts as a molecular filter, allowing only small molecules to pass through to the sampling volume. This filtering, in principle, should enable continuous in vivo drug sensing, removing the necessity for complex microdialysis systems. We use a biological phantom to examine the reliable detection of a fluorescence signal from small dye molecules in the presence of large fluorophores and scatterers. We find that spectral artefacts arising from scatterers and large fluorophores are substantially suppressed, simplifying the spectral analysis. In addition, the measured sampling rate of 157 s is superior to existing in vivo tissue assaying techniques such as microdialysis, which can take tens of minutes.

References

Sep 1, 1986·Acta Physiologica Scandinavica·U Tossman, U Ungerstedt
Nov 1, 1986·Analytical Chemistry·O S Wolfbeis
Jan 1, 1984·Analytical Chemistry·J I PetersonD K Buckhold
Mar 25, 1998·Annals of the New York Academy of Sciences·S L Jacques
Jan 1, 1997·Critical Care : the Official Journal of the Critical Care Forum·E E Roupie
Jan 25, 2003·Journal of Biomedical Optics·Urs Utzinger, Rebecca R Richards-Kortum
Oct 10, 1964·Nature·N S KAPANY, N SILBERTRUST
Jan 28, 2005·Antimicrobial Agents and Chemotherapy·Robert SauermannChristian Joukhadar
Jan 28, 2005·Antimicrobial Agents and Chemotherapy·Suriani Abdul RaniPhilip S Stewart

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Citations

Apr 21, 2006·Physics in Medicine and Biology·Adam M ZyskStephen A Boppart

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