Dialysis disequilibrium syndrome (DDS) in the rat: role of the "reverse urea effect"

Kidney International
S M SilverR H Sterns

Abstract

DDS is characterized by neurologic deterioration and cerebral edema which occurs after hemodialysis. To investigate the pathogenesis of DDDS, we studied the effects of rapid hemodialysis on plasma and brain electrolytes, urea, and osmolality in the rat. Forty-two hours after bilateral nephrectomy, nine uremic rats were hemodialyzed for 90 minutes against dialysate without urea (model of DDS), yielding a decrease in plasma urea from 72 +/- 2 mM to 34 +/- 2 mM (P less than 0.01) and an 8% (29 mOsm/kg) decrease in plasma osmolality. This group was compared to three control groups: 11 uremic animals dialyzed against a bath with urea added so that no fall in plasma urea occurred, and 15 uremic and 12 nonuremic animals that were not dialyzed. In animals dialyzed without urea, compared to uremic non-dialyzed animals, there was a 6% increase in brain water (3.89 +/- 0.04 liter/kg dry wt vs. 3.67 +/- 0.03, P less than 0.01) and an increase in the brain to plasma (urea) ratio (1.30 +/- 0.06 vs. 0.79 +/- 0.05, P less than 0.01). Comparison of these parameters in animals dialyzed without urea versus other control groups yielded similar results. In animals dialyzed without urea, the 53% decrease in plasma urea was associated with only a 13%...Continue Reading

References

Aug 1, 1976·The Journal of Clinical Investigation·A I ArieffV C Lazarowitz
Mar 20, 1978·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A RöckelF S Pedersen
Sep 1, 1978·Kidney International·A I ArieffR Guisado
May 1, 1990·The Journal of Clinical Investigation·Y H LienL Chan
Dec 1, 1989·Kidney International·C R Kleeman
Jan 1, 1967·Canadian Journal of Physiology and Pharmacology·H M PappiusJ B Dossetor
Jun 1, 1964·Archives of Internal Medicine·H PETERSON, A G SWANSON
Feb 24, 1962·Lancet·A C KENNEDYJ C EATON

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Citations

Jun 20, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Diana Zepeda-Orozco, Raymond Quigley
May 24, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Fortunato BattagliaMichele Buemi
Dec 22, 1999·British Journal of Pharmacology·X WangR Wang
Sep 6, 2000·Kidney International·M C HuM M Trinh-Trang-Tan
Jun 8, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C J DoorenbosP J Lamberts
Jun 30, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marie-Marcelle Trinh-Trang-TanLise Bankir
Sep 4, 2008·Seminars in Dialysis·Nilang PatelMandip Panesar
Feb 21, 1998·Journal of Veterinary Internal Medicine·C E LangstonJ A Spano
Jan 3, 2013·Critical Care : the Official Journal of the Critical Care Forum·Pierre EsnaultPhilippe Goutorbe
Mar 24, 2015·The American Journal of the Medical Sciences·Faraz Khan LuniSandeep Vetteth
Dec 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J D KoppleB P Teehan
Jul 22, 2008·Hemodialysis International·Ernesto Lopez-Almaraz, Ricardo Correa-Rotter
Dec 7, 2011·Hemodialysis International·Robertino DilenaAlberto Edefonti
Nov 30, 2004·Clinical Neurology and Neurosurgery·R Brouns, P P De Deyn
Oct 12, 2013·Renal Failure·Gulvahid ShaikhSofia Rubinstein
Nov 11, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Manish Saha, Michael Allon
Oct 25, 2006·Cephalalgia : an International Journal of Headache·M AlessandriM Fanciullacci
Jan 18, 2018·Critical Care Medicine·Eric Michael LiottaMatthew B Maas
Aug 14, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G Gozubatik-CelikA Siva
Dec 5, 2018·Acta Anaesthesiologica Scandinavica·Anton LundKirsten Møller
Jul 22, 2014·Journal of Veterinary Emergency and Critical Care·Cassandra J Ostroski, Edward S Cooper
Dec 4, 2019·NeoReviews·Benjamin L Spector, Jason M Misurac
Jun 13, 2020·PloS One·Masaki FukunagaSumio Hirata
Sep 29, 2020·American Journal of Physiology. Renal Physiology·Justin D SprickJeanie Park
Jan 1, 2001·Hemodialysis International·Mandeep M SahaniTodd S Ing
Oct 1, 2013·Clinical Kidney Journal·Shamir TuchmanKirtida Mistry
Apr 15, 2020·Journal of the Intensive Care Society·Muzzammil Ali, Umar Bakhsh
Jun 20, 2021·Hemodialysis International·Kareem H GenenaJohn C Schwartz
Jul 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S M SilverM L Halperin
Oct 6, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rupesh RainaMadhukar Misra

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