Dialysis reduces portal pressure in patients with chronic hepatitis C.

Artificial Organs
Sandeep KhuranaMark Flasar

Abstract

The purpose of this study was to characterize changes in hepatic venous pressures in patients with chronic hepatitis C. The histology and laboratory data from patients with chronic hepatitis C who underwent a transjugular liver biopsy (TJLB) and hepatic venous pressure gradient measurement were analyzed. Portal hypertension was defined as hepatic venous pressure gradient > or =6 mm Hg. A single pathologist masked to hepatic venous pressure gradient scored liver sections for inflammation and fibrosis. The patients with high-grade inflammation (relative risk [RR] 2.82, P = 0.027, multivariate analysis) and late-stage fibrosis (RR 2.81, P = 0.022) were more likely to have a hepatic venous pressure gradient > or =6 mm Hg, while the patients on dialysis (RR 0.32, P = 0.01) were less likely to have a hepatic venous pressure gradient > or =6 mm Hg. The patients on dialysis (n = 58) had an elevated serum blood urea nitrogen and creatinine when compared with those who were not (n = 75) (47.6 +/- 3.3 and 7.98 +/- 0.4 vs. 25.9 +/- 2.0 and 1.66 +/- 0.22 mg/dL, respectively; P < 0.001). While the hepatic venous pressure gradient increased with the rising levels of liver fibrosis in the latter group (P < 0.01), it did not change in the patie...Continue Reading

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Citations

Mar 16, 2011·Artificial Organs·Paul S Malchesky
Mar 12, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Chen-Hua LiuJia-Horng Kao
Jan 17, 2015·International Surgery·Afshin ParsikiaJorge Ortiz
Apr 18, 2015·International Journal of Surgical Pathology·Hwajeong LeeJingmei Lin

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