Diameter-dependent release of a cisplatin pro-drug from small and large functionalized carbon nanotubes

Nanoscale
Laura MuziAlberto Bianco

Abstract

The use of platinum-based chemotherapeutic drugs in cancer therapy still suffers from severe disadvantages, such as lack of appropriate selectivity for tumor tissues and insurgence of multi-drug resistance. Moreover, drug efficacy can be attenuated by several mechanisms such as premature drug inactivation, reduced drug uptake inside cells and increased drug efflux once internalized. The use of functionalized carbon nanotubes (CNTs) as chemotherapeutic drug delivery systems is a promising strategy to overcome such limitations due to their ability to enhance cellular internalization of poorly permeable drugs and thus increase the drug bioavailability at the diseased site, compared to the free drug. Furthermore, the possibility to encapsulate agents in the nanotubes' inner cavity can protect the drug from early inactivation and their external functionalizable surface is useful for selective targeting. In this study, a hydrophobic platinum(IV) complex was encapsulated within the inner space of two different diameter functionalized multi-walled CNTs (Pt(IV)@CNTs). The behavior of the complexes, compared to the free drug, was investigated on both HeLa human cancer cells and RAW 264.7 murine macrophages. Both CNT samples efficiently i...Continue Reading

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Oct 27, 2015·Physical Chemistry Chemical Physics : PCCP·Mohammed El KhalifiFabien Picaud
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Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Camillo La MesaGianfranco Risuleo

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