PMID: 2511229Nov 1, 1989Paper

Diamine oxidase plasma activities after treatment with heparin and jejunal morphometry in untreated coeliac disease

Journal of Clinical Pathology
G R CorazzaG Gasbarrini

Abstract

Diamine oxidase plasma concentrations after treatment with heparin were measured and compared with the surface to volume ratio of jejunal biopsy samples assessed by a morphometric technique in patients with untreated and treated coeliac disease and in biopsied controls. As expected, enzyme activity was significantly lower in patients with untreated coeliac disease than in patients on a gluten-free diet and in biopsied controls. No difference was found between treated patients and biopsied controls. There was a significant overall correlation between plasma enzyme activity and surface to volume ratio of jejunal mucosa, although two untreated patients without an overt malabsorption syndrome but with a very low surface to volume ratio had normal enzyme activity. This study shows that in coeliac disease plasma diamine oxidase activity after treatment with heparin does not always mirror the extent of the jejunal lesions, particularly in those patients with minimal or unrelated symptoms who would benefit most from a valid screening test to identify their condition.

References

Mar 1, 1987·Digestive Diseases and Sciences·L D'AgostinoG Mazzacca
Aug 1, 1988·Digestive Diseases and Sciences·G R CorazzaG Gasbarrini
Mar 1, 1972·Journal of Clinical Pathology·M S Dunnill, R Whitehead
Sep 26, 1970·British Medical Journal·C C Booth
Jul 1, 1967·The American Journal of Digestive Diseases·D C Roy-ChoudhuryB J Smits
Oct 15, 1984·American Journal of Obstetrics and Gynecology·C F Holinka, E Gurpide
Jul 1, 1980·The Journal of Clinical Investigation·G D LukS B Baylin
Nov 8, 1980·British Medical Journal·C M Swinson, A J Levi
Nov 1, 1961·Archives of Biochemistry and Biophysics·T OKUYAMA, Y KOBAYASHI

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Citations

Nov 1, 1994·Agents and Actions·A Sessa, A Perin
Mar 3, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G F Clough, M K Church

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